Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model
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DOI: 10.1124/dmd.120.000337
Abstract: Volume of distribution (Vd) is a primary pharmacokinetic parameter used to calculate the half-life and plasma concentration-time profile of drugs. Numerous models have been relatively successful in predicting Vd, but the model developed by Korzekwa… read more here.
Keywords: tissue binding; volume distribution; plasma protein; model ... See more keywords