Gelsemine and koumine, principal active ingredients of Gelsemium, exhibit mechanical antiallodynia via spinal glycine receptor activation‐induced allopregnanolone biosynthesis
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DOI: 10.1016/j.bcp.2019.01.014
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Gelsemine, the principal active alkaloid from Gelsemium sempervirens Ait., and koumine, the most dominant alkaloids from Gelsemium elegans Benth., produced antinociception in a variety of rodent models of… read more here.
Keywords: koumine; gelsemine koumine; glycine; mechanical antiallodynia ... See more keywords
Oxidative metabolism of koumine is mainly catalyzed by microsomal CYP3A4/3A5
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DOI: 10.1080/00498254.2016.1213925
Abstract: Abstract 1. Gelsemium elegans Benth (Loganiaceae) is a toxic plant that can be used for committing suicide besides alleviating pains. Its anti-inflammatory and analgesic effect mainly come from its active ingredient, namely koumine. Koumine, an indole… read more here.
Keywords: oxidative metabolism; koumine; metabolism koumine; cyp3a4 3a5 ... See more keywords
Immunoregulatory Effect of Koumine on Nonalcoholic Fatty Liver Disease Rats
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DOI: 10.1155/2019/8325102
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common and important chronic liver disease all over the world. In the present study, we found that koumine, the main and active ingredient isolated from Gelsemium elegans,… read more here.
Keywords: koumine; fatty liver; effect; nonalcoholic fatty ... See more keywords