2‐Carboxyquinoline Boronic Acids as Highly Potent KPC Inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400901
Abstract: The expression of Klebsiella pneumoniae carbapenemase (KPC), a type of carbapenem‐hydrolyzing β‐lactamase, in Gram‐negative bacteria has caused significant bacterial resistance to carbapenems, the antibiotic of last resort. Herein, we describe the discovery of 2‐carboxyquinoline boronic… read more here.
Keywords: potent kpc; highly potent; carboxyquinoline boronic; acids highly ... See more keywords
Virulence genes, capsular and plasmid types of multidrug-resistant CTX-M(-2, -8, -15) and KPC-2-producing Klebsiella pneumoniae isolates from four major hospitals in Brazil.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.01.007
Abstract: We performed a single-month snapshot study of the population diversity of multidrug resistant (MDR) Klebsiella pneumoniae isolates producing carbapenemases and/or extended-spectrum β-lactamases from four major hospitals in Brazil. Isolates produced diverse ESBL (CTX-M-2, -8, -15,… read more here.
Keywords: ctx; pneumoniae; multidrug resistant; klebsiella pneumoniae ... See more keywords
Rapid real-time PCR for the detection of IMP, NDM, VIM, KPC and OXA-48 carbapenemase genes in isolates and spiked stool samples.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.04.002
Abstract: An in-house real-time PCR was developed to detect the carbapenemase genes IMP, NDM, VIM, KPC and OXA-48 from both bacterial colonies and directly from fecal material. The assay is a multiplex PCR performed in two… read more here.
Keywords: carbapenemase; kpc oxa; ndm vim; vim kpc ... See more keywords
The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.102599
Abstract: Background Emergence of KPC-2 and NDM-1-coproducing carbapenem-resistant Klebsiella pneumoniae (KPC-2-NDM-1-CRKP) has escalated threat of CRKP to healthcare. Currently, only 4 isolates had been reported sporadically. It remains unclear how KPC-2-NDM-1-CRKPs emerged, and whether they are… read more here.
Keywords: kpc ndm; klebsiella pneumoniae; kpc; ndm crkp ... See more keywords
Carbapenemases detection testing in the era of ceftazidime-avibactam resistant KPC-producing Enterobacterales: a two-year experience.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2021.02.008
Abstract: OBJECTIVE This study aims to investigate the prevalence of ceftazidime-avibactam (CZA) resistance among carbapenemase-producing Enterobacterales (CPE) blood culture (BC) isolates and the performance of the main carbapenemase phenotypic detection methods to identify KPC variants associated… read more here.
Keywords: ceftazidime avibactam; carbapenemase; resistance; producing enterobacterales ... See more keywords
Non-invasive dynamic monitoring initiation and growth of pancreatic tumor in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2018.11.009
Abstract: The LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mouse is one of the most widely used transgenic models to evaluate tumor characteristics and to develop novel therapies for pancreatic ductal adenocarcinoma (PDAC). There is no report of the effective systemic… read more here.
Keywords: lsl krasg12d; growth; kpc; krasg12d lsl ... See more keywords
Within patient genetic diversity of blaKPC harboring Klebsiellapneumoniae in a Colombian hospital and identification of a new NTEKPC platform
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00887-2
Abstract: Resistance to carbapenems in Klebsiella pneumoniae has been mostly related with the worldwide dissemination of KPC, largely due to the pandemic clones belonging to the complex clonal (CC) 258. To unravel blaKPC post-endemic clinical impact,… read more here.
Keywords: patient genetic; genetic diversity; within patient; blakpc ... See more keywords
ICU environment as a reservoir of KPC-ST307-Klebsiella pneumoniae high-risk clone resistant to ceftazidime-avibactam
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-14987-w
Abstract: We characterized all ceftazidime-avibactam-resistant KPC-producing K. pneumoniae (KPC-Kp) isolates recovered from both patients and environmental samples at the ICU of our hospital in 2020, during the COVID-19 pandemic initiation. Antimicrobial susceptibility testing (Sensititre-EUMDROXF; disk-diffusion) and… read more here.
Keywords: kpc kpc; ceftazidime avibactam; environment; kpc ... See more keywords
Decadal Evolution of KPC-related plasmids in Pseudomonas aeruginosa high-risk clone ST463 in Zhejiang, China
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-07337-5
Abstract: Klebsiella pneumoniae carbapenemase-producing Pseudomonas aeruginosa (KPC-PA) isolates have quickly expanded in China, especially the high-risk clone ST463. We aimed to explore the evolution of KPC-related plasmids driving ST463 clone success. Whole-genome sequencing of 1258 clinical… read more here.
Keywords: pseudomonas aeruginosa; high risk; china; st463 ... See more keywords
Looking beyond ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae: in vitro activity of the novel meropenem-vaborbactam in combination with the old fosfomycin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2021.1909939
Abstract: The spread of production of Klebsiella pneumoniae carbapenemase (KPC) b-lactamase enzyme among the Enterobacterales (EB), in particularly in Klebsiella pneumoniae (KPC-Kp), has become a worldwide health concern given the rising clinical burden of the associated… read more here.
Keywords: kpc producing; combination; activity; resistance ... See more keywords
Novel immunodominant neoepitope in a KPC mouse model of pancreatic cancer allowing identification of tumor-specific T cells
Sign Up to like & getrecommendations! Published in 2025 at "Oncoimmunology"
DOI: 10.1080/2162402x.2025.2489815
Abstract: ABSTRACT The 4662 KPC model is one of the most widely used mouse models of pancreatic cancer. It represents an excluded immune phenotype and closely recapitulates the pathophysiology of pancreatic cancer in humans. We set… read more here.
Keywords: cancer; model; pancreatic cancer; tumor specific ... See more keywords