Virulence genes, capsular and plasmid types of multidrug-resistant CTX-M(-2, -8, -15) and KPC-2-producing Klebsiella pneumoniae isolates from four major hospitals in Brazil.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.01.007
Abstract: We performed a single-month snapshot study of the population diversity of multidrug resistant (MDR) Klebsiella pneumoniae isolates producing carbapenemases and/or extended-spectrum β-lactamases from four major hospitals in Brazil. Isolates produced diverse ESBL (CTX-M-2, -8, -15,… read more here.
Keywords: ctx; pneumoniae; multidrug resistant; klebsiella pneumoniae ... See more keywords
Rapid real-time PCR for the detection of IMP, NDM, VIM, KPC and OXA-48 carbapenemase genes in isolates and spiked stool samples.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.04.002
Abstract: An in-house real-time PCR was developed to detect the carbapenemase genes IMP, NDM, VIM, KPC and OXA-48 from both bacterial colonies and directly from fecal material. The assay is a multiplex PCR performed in two… read more here.
Keywords: carbapenemase; kpc oxa; ndm vim; vim kpc ... See more keywords
The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.102599
Abstract: Background Emergence of KPC-2 and NDM-1-coproducing carbapenem-resistant Klebsiella pneumoniae (KPC-2-NDM-1-CRKP) has escalated threat of CRKP to healthcare. Currently, only 4 isolates had been reported sporadically. It remains unclear how KPC-2-NDM-1-CRKPs emerged, and whether they are… read more here.
Keywords: kpc ndm; klebsiella pneumoniae; kpc; ndm crkp ... See more keywords
Carbapenemases detection testing in the era of ceftazidime-avibactam resistant KPC-producing Enterobacterales: a two-year experience.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2021.02.008
Abstract: OBJECTIVE This study aims to investigate the prevalence of ceftazidime-avibactam (CZA) resistance among carbapenemase-producing Enterobacterales (CPE) blood culture (BC) isolates and the performance of the main carbapenemase phenotypic detection methods to identify KPC variants associated… read more here.
Keywords: ceftazidime avibactam; carbapenemase; resistance; producing enterobacterales ... See more keywords
Non-invasive dynamic monitoring initiation and growth of pancreatic tumor in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2018.11.009
Abstract: The LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mouse is one of the most widely used transgenic models to evaluate tumor characteristics and to develop novel therapies for pancreatic ductal adenocarcinoma (PDAC). There is no report of the effective systemic… read more here.
Keywords: lsl krasg12d; growth; kpc; krasg12d lsl ... See more keywords
Within patient genetic diversity of blaKPC harboring Klebsiellapneumoniae in a Colombian hospital and identification of a new NTEKPC platform
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00887-2
Abstract: Resistance to carbapenems in Klebsiella pneumoniae has been mostly related with the worldwide dissemination of KPC, largely due to the pandemic clones belonging to the complex clonal (CC) 258. To unravel blaKPC post-endemic clinical impact,… read more here.
Keywords: patient genetic; genetic diversity; within patient; blakpc ... See more keywords
Looking beyond ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae: in vitro activity of the novel meropenem-vaborbactam in combination with the old fosfomycin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2021.1909939
Abstract: The spread of production of Klebsiella pneumoniae carbapenemase (KPC) b-lactamase enzyme among the Enterobacterales (EB), in particularly in Klebsiella pneumoniae (KPC-Kp), has become a worldwide health concern given the rising clinical burden of the associated… read more here.
Keywords: kpc producing; combination; activity; resistance ... See more keywords
High ceftazidime hydrolysis activity and porin OmpK35 deficiency contribute to the decreased susceptibility to ceftazidime/avibactam in KPC-producing Klebsiella pneumoniae
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx066
Abstract: Objectives To investigate mechanisms for the decreased susceptibility to ceftazidime/avibactam in KPC-producing Klebsiella pneumoniae (KPC-KP). Methods A total of 24 isolates, 8 each with ceftazidime/avibactam MICs of 4-8, 1-2 and ≤0.5 mg/L, were randomly selected from… read more here.
Keywords: ceftazidime avibactam; susceptibility; hydrolysis; hydrolysis activity ... See more keywords
Ceftazidime/avibactam resistance associated with L169P mutation in the omega loop of KPC-2
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkz026
Abstract: Objectives Ceftazidime/avibactam resistance due to mutation in the omega loop of KPC-2 has been documented in vitro and in vivo. This study evaluated the mechanism of ceftazidime/avibactam resistance in a KPC-2-expressing Klebsiella pneumoniae isolated from… read more here.
Keywords: ceftazidime avibactam; avibactam resistance; ceftazidime; kpc ... See more keywords
The rocky road to quiescence: compaction and quenching of quasar host galaxies at z ∼ 2
Sign Up to like & getrecommendations! Published in 2020 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/staa3433
Abstract: We resolve the host galaxies of seven gravitationally lensed quasars at redshift 1.5 to 2.8 using observations with the Atacama Large (sub-)Millimetre Array. Using a visibility-plane lens modelling technique, we create pixellated reconstructions of the… read more here.
Keywords: host galaxies; star formation; kpc; quasar host ... See more keywords
Spatially resolved gas flows around the milky way
Sign Up to like & getrecommendations! Published in 2022 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/stac504
Abstract: We present spatially resolved measurements of cool gas flowing into and out of the Milky Way (MW), using archival ultraviolet spectra of background quasars from the Hubble Space Telescope/Cosmic Origins Spectrograph. We co-add spectra of… read more here.
Keywords: spatially resolved; gas; kpc; milky way ... See more keywords