The Epidemiology, Evolution, and Treatment of KPC-Producing Organisms
Sign Up to like & getrecommendations! Published in 2018 at "Current Infectious Disease Reports"
DOI: 10.1007/s11908-018-0617-x
Abstract: Purpose of ReviewThe purpose of this review is to investigate the evolution and epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and the current and future treatment options for infections caused by KPC-producing isolates.Recent FindingsThe emergence… read more here.
Keywords: producing organisms; infections caused; treatment; epidemiology ... See more keywords
Dialysis drains as a possible source for carbapenem-resistant pathogens causing an ICU outbreak
Sign Up to like & getrecommendations! Published in 2018 at "Infection"
DOI: 10.1007/s15010-018-1239-9
Abstract: Objective designWe describe a case series of patients colonized with KPC-producing Enterobacteriaceae related to dialysis drains at patient’s bedside.SettingThe study was set at the intensive care unit (ICU) of a tertiary referral hospital.PatientsIn March 2016,… read more here.
Keywords: drains possible; producing enterobacteriaceae; possible source; dialysis drains ... See more keywords
Native mitral valve endocarditis associated with KPC producing Serratia marcescens bacteremia successfully treated with mitral valve replacement and ceftazidime-avibactam
Sign Up to like & getrecommendations! Published in 2021 at "IDCases"
DOI: 10.1016/j.idcr.2021.e01137
Abstract: Highlights • First case of native valve endocarditis due to Klebsiella Pneumomiae carbapenemase (KPC) producing Serratia marcescens.• Patient underwent mitral valve replacement and was treated with monotherapy ceftazidime-avibactam during 6 weeks.• Long term treatment with… read more here.
Keywords: ceftazidime avibactam; valve endocarditis; producing serratia; mitral valve ... See more keywords
Genomic analysis of the first isolate of KPC-2-producing Klebsiella pneumoniae from Uruguay.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2018.09.001
Abstract: OBJECTIVES Since KPC-2-producing Klebsiella pneumoniae are associated with successful dissemination of a major clone, defined as sequence type 258 (ST258), the aim of this study was to perform whole-genome sequencing (WGS) of the first colistin-resistant… read more here.
Keywords: producing klebsiella; analysis; pneumoniae; first isolate ... See more keywords
Performance of Polymyxin B Etest® in a setting of high prevalence of KPC-producing Klebsiella pneumoniae.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2020.02.006
Abstract: OBJECTIVES Resistance to polymyxins has been increasing in many regions and appropriate determination of polymyxin susceptibility is now a major challenge worldwide. Many clinical laboratories rely on gradient diffusion methods to assess polymyxin susceptibility, although… read more here.
Keywords: susceptibility; pneumoniae; performance polymyxin; polymyxin ... See more keywords
Expansion of KPC-producing Enterobacterales in four large hospitals in Hanoi, Vietnam.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2021.09.007
Abstract: OBJECTIVES Carbapenem resistance among nosocomial Gram-negative bacteria in Vietnam is high and increasing, including among Enterobacterales. In this study, we assessed the presence of one of the main carbapenemase genes, blaKPC, among carbapenem-resistant Enterobacterales from… read more here.
Keywords: four large; hospitals hanoi; enterobacterales four; large hospitals ... See more keywords
Proof‑of‑concept study to quantify changes in intestinal loads of KPC-producing Klebsiella pneumoniae in colonized patients following selective digestive decontamination with oral gentamicin.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2022.04.010
Abstract: OBJECTIVES To monitor quantitatively the extent of intestinal colonization by KPC-producing Klebsiella pneumoniae (KPC-Kp) in colonized patients who receive selective digestive decontamination (SDD) with oral gentamicin. METHODS We developed a real-time quantitative PCR (qPCR) method for… read more here.
Keywords: kpc producing; producing klebsiella; gentamicin; colonized patients ... See more keywords
Genomic analysis of the first KPC-producing Klebsiella pneumoniae isolated from a patient in Riyadh: A new public health concern in Saudi Arabia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2020.01.003
Abstract: Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have been isolated from human patients in many countries across the globe but rarely in Saudi Arabia. Here we provide the genomic characterization of the first KPC-producing K. pneumoniae isolated… read more here.
Keywords: pneumoniae isolated; first kpc; saudi arabia; klebsiella pneumoniae ... See more keywords
Looking beyond ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae: in vitro activity of the novel meropenem-vaborbactam in combination with the old fosfomycin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2021.1909939
Abstract: The spread of production of Klebsiella pneumoniae carbapenemase (KPC) b-lactamase enzyme among the Enterobacterales (EB), in particularly in Klebsiella pneumoniae (KPC-Kp), has become a worldwide health concern given the rising clinical burden of the associated… read more here.
Keywords: kpc producing; combination; activity; resistance ... See more keywords
KPC-3-producing ST167 Escherichia coli from mussels bought at a retail market in Tunisia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx124
Abstract: Unité de recherche: Résistances bactériennes émergentes et sécurité des soins ‘UR12SP37’, Laboratoire de Microbiologie, Hôpital Universitaire Sahloul, Sousse, Tunisia; Institut Supérieur des Sciences Appliquées et de Technologie de Mahdia, Université de Monastir, Mahdia, Tunisia; Service… read more here.
Keywords: monastir; paris france; tunisia; sousse ... See more keywords
In vitro activity of meropenem combined with vaborbactam against KPC-producing Enterobacteriaceae in China
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dky251
Abstract: Background Vaborbactam is a novel inhibitor of serine β-lactamases, including KPCs, which predominate in China. It is being developed in combination with meropenem. Methods Using the broth microdilution method, the in vitro activity of meropenem/vaborbactam… read more here.
Keywords: vaborbactam; producing enterobacteriaceae; meropenem; activity ... See more keywords