Importin KPNA2 confers HIV-1 pre-integration complex nuclear import by interacting with the capsid protein.
Sign Up to like & getrecommendations! Published in 2022 at "Antiviral research"
DOI: 10.1016/j.antiviral.2022.105289
Abstract: For human immunodeficiency virus 1 (HIV-1) to infect non-dividing cells, pre-integration complex (PIC) must be transported into the nucleus within the replication cycle. We previously reported that the karyopherin β1 (KPNB1)-nucleoporin Pom121 pathway, related to… read more here.
Keywords: import; pic nuclear; nuclear import; kpna2 ... See more keywords
Upregulated KPNA2 promotes hepatocellular carcinoma progression and indicates prognostic significance across human cancer types
Sign Up to like & getrecommendations! Published in 2019 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmz003
Abstract: Hepatocellular carcinoma (HCC) is one of the most aggressive cancers worldwide. Identification of the molecular mechanisms underlying the development and progression of HCC is particularly important. Here, we demonstrated the expression pattern, clinical significance, and… read more here.
Keywords: hepatocellular carcinoma; cancer types; kpna2; expression ... See more keywords
Abstract 3986: Regulation mechanism and clinical significance of KPNA2 promotes MDSCs infiltrating in epithelial ovarian cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3986
Abstract: Myeloid-Derived Suppressor Cells (MDSCs) are a population of immune cells that negatively regulate immune responses, which could promote tumor invasion and metastasis. Recently research has revealed that tumor could actively reshape the immune-microenvironment for its… read more here.
Keywords: regulation mechanism; kpna2; ovarian cancer; cancer ... See more keywords
Silencing of the nucleocytoplasmic shuttling protein karyopherin a2 promotes cell-cycle arrest and apoptosis in glioblastoma multiforme
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26033
Abstract: We have previously shown that the nucleocytoplasmic carrier karyopherin a2 (KPNA2) is overexpressed in glioblastoma multiforme (GBM) whereas its expression is inversely associated with patient prognosis. However, the promoting role of KPNA2 in gliomagenesis is… read more here.
Keywords: kpna2; gbm; cell cycle; glioblastoma multiforme ... See more keywords
Circular RNA circ_0079593 promotes glioma development through regulating KPNA2 expression by sponging miR-499a-5p.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202001_20186
Abstract: OBJECTIVE Glioma is a common aggressive cancer and a major public health problem worldwide, with high incidence, recurrence, and mortality. Circular RNA (circRNA) has been reported to be involved in glioma, but the role of… read more here.
Keywords: kpna2; glioma; expression; circ 0079593 ... See more keywords
SMARCC1 Enters the Nucleus via KPNA2 and Plays an Oncogenic Role in Bladder Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.902220
Abstract: Background: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily C member 1 (SMARCC1), a component of the SWI/SNF complex, is thought to be an oncogene in several kinds of cancer. Materials and methods: The potential interaction… read more here.
Keywords: kpna2; smarcc1; role; bladder cancer ... See more keywords