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   Articles with "kpna2" as a keyword



Importin KPNA2 confers HIV-1 pre-integration complex nuclear import by interacting with the capsid protein.

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recommendations! Published in 2022 at "Antiviral research"

DOI: 10.1016/j.antiviral.2022.105289

Abstract: For human immunodeficiency virus 1 (HIV-1) to infect non-dividing cells, pre-integration complex (PIC) must be transported into the nucleus within the replication cycle. We previously reported that the karyopherin β1 (KPNB1)-nucleoporin Pom121 pathway, related to… read more here.

Keywords: import; pic nuclear; nuclear import; kpna2 ... See more keywords

Upregulated KPNA2 promotes hepatocellular carcinoma progression and indicates prognostic significance across human cancer types

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recommendations! Published in 2019 at "Acta Biochimica et Biophysica Sinica"

DOI: 10.1093/abbs/gmz003

Abstract: Hepatocellular carcinoma (HCC) is one of the most aggressive cancers worldwide. Identification of the molecular mechanisms underlying the development and progression of HCC is particularly important. Here, we demonstrated the expression pattern, clinical significance, and… read more here.

Keywords: hepatocellular carcinoma; cancer types; kpna2; expression ... See more keywords

MiR‐20a‐5p Inhibits Bladder Cancer Proliferation and Migration by Targeting KPNA2

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recommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.70785

Abstract: Bladder cancer (BC) is one of the 10 most common cancers in the world, and its recurrence and metastasis are the main causes of death in BC patients. Exploring the molecular mechanisms of BC pathogenesis… read more here.

Keywords: kpna2; proliferation migration; expression; mir 20a ... See more keywords

Abstract 3986: Regulation mechanism and clinical significance of KPNA2 promotes MDSCs infiltrating in epithelial ovarian cancer

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-3986

Abstract: Myeloid-Derived Suppressor Cells (MDSCs) are a population of immune cells that negatively regulate immune responses, which could promote tumor invasion and metastasis. Recently research has revealed that tumor could actively reshape the immune-microenvironment for its… read more here.

Keywords: regulation mechanism; kpna2; ovarian cancer; cancer ... See more keywords
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KPNA2 enhances autophagy through activation of the non-canonical NF-κB signaling pathway, thereby promoting the induction of bortezomib resistance in multiple myeloma

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-7478

Abstract: KPNA2 enhances autophagy through activation of the non-canonical NF-κB signaling pathway, thereby promoting the induction of bortezomib resistance in multiple myeloma Background: Multiple myeloma (MM) is a malignant plasma cell disorder characterized by clonal expansion… read more here.

Keywords: bortezomib; multiple myeloma; resistance; non canonical ... See more keywords

Normal male fertility in a mouse model of KPNA2 deficiency

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recommendations! Published in 2024 at "PLOS ONE"

DOI: 10.1371/journal.pone.0304189

Abstract: The nuclear transport of proteins is mediated by karyopherins and has been implicated to be crucial for germ cell and embryonic development. Deletion of distinct members of the karyopherin alpha family has been shown to… read more here.

Keywords: mice; fertility; germ cell; kpna2 ... See more keywords

Silencing of the nucleocytoplasmic shuttling protein karyopherin a2 promotes cell-cycle arrest and apoptosis in glioblastoma multiforme

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recommendations! Published in 2018 at "Oncotarget"

DOI: 10.18632/oncotarget.26033

Abstract: We have previously shown that the nucleocytoplasmic carrier karyopherin a2 (KPNA2) is overexpressed in glioblastoma multiforme (GBM) whereas its expression is inversely associated with patient prognosis. However, the promoting role of KPNA2 in gliomagenesis is… read more here.

Keywords: kpna2; gbm; cell cycle; glioblastoma multiforme ... See more keywords

Circular RNA circ_0079593 promotes glioma development through regulating KPNA2 expression by sponging miR-499a-5p.

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recommendations! Published in 2020 at "European review for medical and pharmacological sciences"

DOI: 10.26355/eurrev_202001_20186

Abstract: OBJECTIVE Glioma is a common aggressive cancer and a major public health problem worldwide, with high incidence, recurrence, and mortality. Circular RNA (circRNA) has been reported to be involved in glioma, but the role of… read more here.

Keywords: kpna2; glioma; expression; circ 0079593 ... See more keywords

SMARCC1 Enters the Nucleus via KPNA2 and Plays an Oncogenic Role in Bladder Cancer

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.902220

Abstract: Background: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily C member 1 (SMARCC1), a component of the SWI/SNF complex, is thought to be an oncogene in several kinds of cancer. Materials and methods: The potential interaction… read more here.

Keywords: kpna2; smarcc1; role; bladder cancer ... See more keywords