A Recurrent KPNA3 Missense Variant Causing Infantile Pure Spastic Paraplegia
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DOI: 10.1002/ana.26297
Abstract: With great interest we read the study of Schob et al in Annals of Neurology identifying 6 dominantly inherited or de novo KPNA3 mutations, in 8 patients from 5 families. In doing so, they implicate… read more here.
Keywords: kpna3; spastic paraplegia; missense variant;
KPNA3 Confers Sorafenib Resistance to Advanced Hepatocellular Carcinoma via TWIST Regulated Epithelial-Mesenchymal Transition
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DOI: 10.7150/jca.31448
Abstract: Sorafenib, a multikinase inhibitor, is a new standard treatment for patients with advanced hepatocellular carcinoma (HCC). However, resistance to this regimen is frequently observed in clinical practice, and the molecular basis of this resistance remains… read more here.
Keywords: hepatocellular carcinoma; kpna3; expression; resistance ... See more keywords