Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing
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DOI: 10.1093/nar/gkac123
Abstract: Abstract Precision epigenome editing has gained significant attention as a method to modulate gene expression without altering genetic information. However, a major limiting factor has been that the gene expression changes are often transient, unlike… read more here.
Keywords: ezh2; epigenome editing; dcas9 dnmt3; krab dcas9 ... See more keywords