KRAS Activating Signaling Triggers Arteriovenous Malformations.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2018.04.007
Abstract: The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous… read more here.
Keywords: triggers arteriovenous; activating signaling; kras activating; signaling triggers ... See more keywords
Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-22-0035
Abstract: Members of the family of RAS proto-oncogenes, discovered just over 40 years ago, were among the first cancer-initiating genes to be discovered. Of the three RAS family members, KRAS is the most frequently mutated in… read more here.
Keywords: classification kras; kras activating; activating mutations; mutations implications ... See more keywords