Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.
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DOI: 10.1021/acs.jmedchem.1c01334
Abstract: RAS proteins are central in the proliferation of many types of cancer, but a general approach toward the identification of pan-mutant RAS inhibitors has remained unresolved. In this work, we describe the application of a… read more here.
Keywords: novel kras; kras binding; site application; binding site ... See more keywords