Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.031
Abstract: SUMMARY Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial fragmentation and tumor growth through Erk phosphorylation of the mitochondrial… read more here.
Keywords: drp1 promotes; kras driven; growth; tumor growth ... See more keywords
Discovery of Orally Bioavailable SOS1 Inhibitors for Suppressing KRAS-Driven Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00986
Abstract: The interaction between son of sevenless 1 (SOS1) gene and Kirsten rat sarcoma viral oncogene (KRAS) is crucial for activating signals of proliferation and survival in a range of cancers. We previously discovered compound 40a… read more here.
Keywords: bioavailable sos1; orally bioavailable; kras driven; suppressing kras ... See more keywords
Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01517
Abstract: KRAS mutations (G12C, G12D, etc.) are implicated in the oncogenesis and progression of many refractory cancers. Son of sevenless homolog 1 (SOS1) is a key regulator of KRAS to modulate KRAS from inactive to active… read more here.
Keywords: optimization orally; design structural; structural optimization; kras driven ... See more keywords
Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis
Sign Up to like & getrecommendations! Published in 2017 at "Nature medicine"
DOI: 10.1038/nm.4407
Abstract: Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur… read more here.
Keywords: keap1 loss; lung cancer; cancer; kras driven ... See more keywords
KRAS drives immune evasion in a genetic model of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21736-w
Abstract: Immune evasion is a hallmark of KRAS-driven cancers, but the underlying causes remain unresolved. Here, we use a mouse model of pancreatic ductal adenocarcinoma to inactivate KRAS by CRISPR-mediated genome editing. We demonstrate that at… read more here.
Keywords: immune evasion; pancreatic cancer; model pancreatic; kras driven ... See more keywords
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2018.1450708
Abstract: ABSTRACT Defects in basal autophagy limit the nutrient supply from recycling of intracellular constituents. Despite our understanding of the prosurvival role of macroautophagy/autophagy, how nutrient deprivation, caused by compromised autophagy, affects oncogenic KRAS-driven tumor progression… read more here.
Keywords: tumorigenesis; oncogenic kras; driven tumor; autophagic reliance ... See more keywords
FAM111B enhances proliferation of KRAS‐driven lung adenocarcinoma by degrading p16
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14483
Abstract: Lung cancer is a common type of cancer that represents a health problem worldwide; lung adenocarcinoma (LUAD) is a major subtype of lung cancer. Although several treatments for LUAD have been developed, the mortality rate… read more here.
Keywords: lung adenocarcinoma; proliferation; fam111b; cancer ... See more keywords
Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-3082
Abstract: In this issue of Cancer Research, Rozeveld and colleagues present intriguing evidence of the importance of lipid droplets and hormone-sensitive lipase (HSL) in regulating the aggressive nature of pancreatic cancer. Initially demonstrating a dependency of… read more here.
Keywords: fats mets; cancer; mets kras; kras driven ... See more keywords
Abstract B048: Activation of PKC inhibits oncogenic KRAS-driven malignancies
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b048
Abstract: The extremely high mutation rate of KRAS in three of the top four deadly cancers (lung, colon, and pancreas) makes it a major target in anticancer drug discovery. However, no effective anti-KRAS inhibitors have yet… read more here.
Keywords: driven malignancies; prostratin; activation pkc; pkc ... See more keywords
Abstract 1920: Prostaglandin E2 accumulation enhances the expansion of ALDH1-positive cells and Kras-driven tumorigenesis in the pancreas
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1920
Abstract: Background: Chronic inflammation is known to be a risk factor of carcinogenesis and tumor development, and it was demonstrated that oral aspirin intake reduced cancer-related death including pancreatic ductal adenocarcinoma (PDAC) through inhibiting prostaglandin synthases.… read more here.
Keywords: pdac; aldh1; pge2; expression ... See more keywords
Abstract 4053: Mucin 5ac as a potential therapeutic target for KRAS-driven lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-4053
Abstract: Lung cancer continues to be the leading cause of cancer death in the United States, with more than 140,000 deaths per year. One of the main types of lung cancer is non-small cell lung cancer… read more here.
Keywords: lung adenocarcinoma; mucin 5ac; muc5ac; lung cancer ... See more keywords