KRAS as a druggable target in NSCLC: Rising like a phoenix after decades of development failures.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2020.101978
Abstract: Cancers of nearly all lineages harbor alterations that deregulate mitogen-activated protein kinase signaling, a crucial signaling pathway for tumor formation and maintenance. Of these, KRAS mutations are the most frequent gain-of-function alterations found in patients… read more here.
Keywords: nsclc rising; target; kras druggable; druggable target ... See more keywords
KRAS: A Druggable Target in Colon Cancer Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084120
Abstract: Mutations in KRAS are among the most frequent aberrations in cancer, including colon cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule inhibition. Moreover, its elevated affinity to cellular guanosine… read more here.
Keywords: target colon; druggable target; kras druggable; cancer ... See more keywords