Abstract IA25: Systematic interrogation of KRAS function
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DOI: 10.1158/1557-3125.ras23-ia25
Abstract: Oncogenic mutations of KRAS occur frequently in pancreas, lung and colon cancers. Recent efforts to target particular KRAS alleles or RAS effector pathways has led to clinical responses but resistance to therapy limits the effectiveness… read more here.
Keywords: systematic interrogation; abstract ia25; kras function; driven cancers ... See more keywords
Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function
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DOI: 10.26508/lsa.201900431
Abstract: KRAS-dependent cancer cell growth is inhibited by disrupting phosphatidylserine transport to the plasma membrane by genetic knockdown of lipid exchangers ORP5 and ORP8 or by inhibition of PI4KIIIα. The small GTPase KRAS, which is frequently… read more here.
Keywords: ptdser; content; kras function; orp5 orp8 ... See more keywords