Abstract B03: Biologic and biochemical interactions of NF1 GAP on KRAS G13x mutations
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DOI: 10.1158/1557-3125.ras18-b03
Abstract: KRAS mutations are common among 30% of cancers and promote tumor growth by constitutively activating the MAPK pathway independent of mitogenic stimuli. KRAS mutations at codons 12, 13, or 61 stabilize the KRAS-GTP complex by… read more here.
Keywords: gap; biologic biochemical; nf1 p120; kras g13d ... See more keywords