KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13719
Abstract: Intraductal papillary mucinous neoplasms (IPMNs) are potential precursor lesions of pancreatic cancer. We assessed the efficacy of screening for KRAS proto‐oncogene, GTPase (KRAS), and GNAS complex locus (GNAS) mutations in cell‐free DNA (cfDNA)—using digital droplet… read more here.
Keywords: gnas mutations; kras gnas; papillary mucinous; mucinous neoplasms ... See more keywords
Activating KRAS and GNAS mutations in heterotopic submucosal glands of the stomach
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DOI: 10.1007/s00535-022-01863-x
Abstract: The heterotopic submucosal gland (HSG) is a common incidental finding in gastrectomy specimens. The majority of HSGs are small incidental lesions, which are also known as gastritis cystica profunda. However, larger lesions may appear as… read more here.
Keywords: hsg lesions; activating kras; mutations heterotopic; kras gnas ... See more keywords
GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling.
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DOI: 10.1053/j.gastro.2018.08.006
Abstract: BACKGROUND & AIMS Mutations at hotspots in GNAS, which encodes stimulatory G-protein, α subunits, are detected in approximately 60% of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. We generated mice with KRAS-induced IPMNs that… read more here.
Keywords: mice express; activated kras; kras gnas; mice ... See more keywords