IKKβ targeting reduces KRAS-induced lung cancer angiogenesis in vitro and in vivo: A potential anti-angiogenic therapeutic target.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.02.027
Abstract: OBJECTIVES The ability of tumor cells to drive angiogenesis is an important cancer hallmark that positively correlates with metastatic potential and poor prognosis. Therefore, targeting angiogenesis is a rational therapeutic approach and dissecting proangiogenic pathways… read more here.
Keywords: kras induced; angiogenesis; ikk; lung cancer ... See more keywords
Trametinib as a promising therapeutic option in alleviating vascular defects in an endothelial KRAS-induced mouse model.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac169
Abstract: Somatic activating Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations have been reported in patients with arteriovenous malformations. By producing LSL-Kras (G12D); Cdh5 (PAC)-CreERT2 [iEC-Kras (G12D*)] mice, we hoped to activate KRAS within vascular endothelial… read more here.
Keywords: kras induced; kras g12d; trametinib; iec kras ... See more keywords
IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-15-1684
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies lacking effective therapeutic strategies. Here, we show that the noncanonical IκB-related kinase, IKBKE, is a critical oncogenic effector during KRAS-induced pancreatic transformation. Loss of IKBKE… read more here.
Keywords: kras induced; ikbke required; pancreatic tumorigenesis; induced pancreatic ... See more keywords
FOSL1 Promotes Kras‐induced Lung Cancer through Amphiregulin and Cell Survival Gene Regulation
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0164oc
Abstract: &NA; The FOSL1/AP‐1 transcription factor regulates gene expression, thereby controlling various pathophysiological processes. It is a major effector of RAS‐ERK1/2 signaling and is activated in human lung epithelia by tumorigenic stimuli. Recent evidence shows an… read more here.
Keywords: kras induced; lung cancer; fosl1; gene ... See more keywords