KRAS Inhibitors- yes but what next? Direct targeting of KRAS- vaccines, adoptive T cell therapy and beyond.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2021.102309
Abstract: Kirsten rat sarcoma viral oncogene homolog (KRAS) is a proto-oncogene of the RAS-MAPK pathway. KRAS mutations are present in a variety of malignancies including lung, colorectal, and pancreatic cancer. Until the recent approval of sotorasib,… read more here.
Keywords: kras inhibitors; cell therapy; adoptive cell; vaccines adoptive ... See more keywords
Novel Tricyclic Compounds as KRAS Inhibitors for Treating Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00140
Abstract: Provided herein are novel tricyclic compounds as KRAS inhibitors, pharmaceutical compositions, use of such compounds in treating cancer and processes for preparing such compounds. read more here.
Keywords: kras inhibitors; novel tricyclic; treating cancer; tricyclic compounds ... See more keywords
Novel approaches for the development of direct KRAS inhibitors: structural insights and drug design
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2029842
Abstract: ABSTRACT Introduction Hyperactivated RAS signaling is reported in 13% of all human cancers, in which ~80% resulted due to KRAS mutations alone. Direct inhibition of KRAS is an important aspect in treating KRAS-related tumors. Despite… read more here.
Keywords: small molecule; structural insights; kras inhibitors; development ... See more keywords
Abstract 549: Characterization of the selective inhibitory effect of KRas inhibitors in different cellular assay formats
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-549
Abstract: The proto-oncogene KRas is a well-described small GTPase that functions as a molecular switch for major physiological signaling pathways involved in cell proliferation, differentiation and survival. It has been shown that activating mutations in KRas… read more here.
Keywords: selective inhibitory; different cellular; inhibitory effect; effect ... See more keywords