PO-209 Biological characterisation of specific KRAS mutations: from basic biology to response to treatment
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DOI: 10.1136/esmoopen-2018-eacr25.244
Abstract: Introduction KRAS is one of the most frequently mutated oncogenes in cancer and KRAS mutations are commonly associated with resistance to therapy and poor prognosis. KRAS is still not directly druggable, therefore current therapeutic strategies… read more here.
Keywords: response; vitro vivo; specific kras; biology ... See more keywords
Abstract 1825: Tumor-targeted knockdown of KRAS mutants with novel Centyrin:siRNA conjugates
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DOI: 10.1158/1538-7445.am2020-1825
Abstract: KRAS has been the quintessential undruggable oncogene for many years. Although there have been recently described small molecule inhibitors of KRAS, these molecules only target a specific mutant form, KRAS G12C. The KRAS G12C mutation… read more here.
Keywords: centyrin; centyrin sirna; knockdown kras; kras mutants ... See more keywords
Abstract 3487: Molecular dynamic simulations of RAS family protein interactions: Mutant KRAS binding with wildtype HRAS and NRAS
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DOI: 10.1158/1538-7445.am2024-3487
Abstract: Introduction: Mutations in the KRAS, HRAS, and NRAS genes are frequently associated with worse patient outcomes. Previous analyses of the structure and function of the associated proteins have been explored but not conclusively. The actual… read more here.
Keywords: hras nras; kras mutants; protein; wildtype hras ... See more keywords
Abstract 6493: CRISPR-directed prime editing sensitizes EGFR inhibitor by correcting oncogenic KRAS mutants In NSCLC
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DOI: 10.1158/1538-7445.am2024-6493
Abstract: EGFR inhibitor has been demonstrated with huge therapeutic potential in advanced non-small cell lung cancer (NSCLC), while the patients carrying KRAS mutation had poor response to EGFR inhibitor. KRAS mutation is the most frequent molecular… read more here.
Keywords: crispr directed; kras mutants; egfr inhibitor; directed prime ... See more keywords
Abstract PHB05: Mechanism-based computational models to study interplay between EGFR inhibitors and KRAS mutants
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DOI: 10.1158/1538-7445.camodels2020-phb05
Abstract: An early genotype-to-phenotype relationship in cancer personalized medicine was that KRAS mutations confer resistance to EGFR inhibitors in colorectal cancer. Confusingly, phase 3 clinical trials found that patients with the KRAS G13D mutation were an… read more here.
Keywords: egfr inhibitors; cancer; computational models; kras g13d ... See more keywords