Significance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22579
Abstract: Biliary strictures can be caused by benign and malignant conditions. A biliary duct brushing diagnosis can be challenging because of low cellularity and overlapping morphology among different entities, leading to a variable reported sensitivity. This… read more here.
Keywords: significance kras; mutation testing; testing biliary; cytology ... See more keywords
Lifespan Kras mutation levels in lung and liver of B6C3F1 mice
Sign Up to like & getrecommendations! Published in 2018 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22198
Abstract: Somatic mutations accumulate in the human genome and are correlated with increased cancer incidence as humans age. The standard model for studying the carcinogenic effects of exposures for human risk assessment is the rodent 2‐year… read more here.
Keywords: mutation; kras mutation; age; b6c3f1 mice ... See more keywords
A Deep Learning Model Based on MRI and Clinical Factors Facilitates Noninvasive Evaluation of KRAS Mutation in Rectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28237
Abstract: Recent studies showed the potential of MRI‐based deep learning (DL) for assessing treatment response in rectal cancer, but the role of MRI‐based DL in evaluating Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation remains unclear. read more here.
Keywords: kras mutation; rectal cancer; deep learning; learning model ... See more keywords
KRAS mutation allele frequency threshold alters prognosis in right‐sided resected pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26860
Abstract: Next‐generation sequencing (NGS) provides information on genetic mutations and mutant allele frequency in tumor specimens. We investigated the prognostic significance of KRAS mutant allele frequency in patients with right‐sided pancreatic ductal adenocarcinoma (PDAC) treated with… read more here.
Keywords: right sided; frequency; mutation allele; allele frequency ... See more keywords
Pulmonary Inflammation and KRAS Mutation in Lung Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-63046-1_5
Abstract: Chronic lung infection and lung cancer are two of the most important pulmonary diseases. Respiratory infection and its associated inflammation have been increasingly investigated for their role in increasing the risk of respiratory diseases including… read more here.
Keywords: kras mutation; inflammation; lung cancer; cancer ... See more keywords
Feasibility of MRI Radiomics for Predicting KRAS Mutation in Rectal Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Current Medical Science"
DOI: 10.1007/s11596-020-2298-6
Abstract: The mutation status of KRAS is a significant biomarker in the prognosis of rectal cancer. This study investigated the feasibility of MRI-based radiomics in predicting the mutation status of KRAS with a composite index which… read more here.
Keywords: kras mutation; rectal cancer; predicting kras; feasibility mri ... See more keywords
The Impact of KRAS Mutation on the Presentation and Prognosis of Non-Metastatic Colon Cancer: an Analysis from the National Cancer Database
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Gastrointestinal Surgery"
DOI: 10.1007/s11605-020-04543-4
Abstract: Approximately 40% of colorectal cancers have a KRAS mutation. The prognostic significance of KRAS mutations in patients with non-metastatic colon cancer has not been well elucidated. The National Cancer Database (NCDB) was used to analyze… read more here.
Keywords: kras mutation; analysis; colon; colon cancer ... See more keywords
Early assessment of KRAS mutation in cfDNA correlates with risk of progression and death in advanced non-small-cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-0833-7
Abstract: Liquid biopsy has the potential to monitor biological effects of treatment. KRAS represents the most commonly mutated oncogene in Caucasian non-small-cell lung cancer (NSCLC). The aim of this study was to explore association of dynamic… read more here.
Keywords: kras mutation; cell lung; non small; cancer ... See more keywords
Reliability of digital PCR in detecting KRAS mutation in colorectal cancer using plasma sample
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000021171
Abstract: Abstract Background: Test on the KRAS somatic mutation status is necessary before cetuximab and panitumumab treatments are given to colorectal cancer patients. Metastatic colorectal cancer patients sometimes lack tumor tissue samples, and the testing of… read more here.
Keywords: colorectal cancer; digital pcr; kras mutation; mutation ... See more keywords
KRAS mutation is predictive of outcome in patients with pulmonary sarcomatoid carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Histopathology"
DOI: 10.1111/his.13505
Abstract: Pulmonary sarcomatoid carcinoma (PSC) is a poorly differentiated non‐small‐cell lung carcinoma (NSCLC) with aggressive behaviour. This study aimed to evaluate the prognostic clinicopathological and genetic characteristics of PSCs. read more here.
Keywords: kras mutation; carcinoma; mutation predictive; predictive outcome ... See more keywords
Key differences between 13 KRAS mutation detection technologies and their relevance for clinical practice
Sign Up to like & getrecommendations! Published in 2017 at "ESMO Open"
DOI: 10.1136/esmoopen-2017-000235
Abstract: Click here and here to see the linked articles Introduction This study assessed KRAS mutation detection and functional characteristics across 13 distinct technologies and assays available in clinical practice, in a blinded manner. Methods Five… read more here.
Keywords: mutation detection; kras mutation; clinical practice;