Real‐world retrospective study of KRAS mutations in advanced non–small cell lung cancer in the era of immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34731
Abstract: KRAS mutation‐positive (KRAS‐positive), advanced nonsmall‐cell lung cancer (NSCLC) is characterized by a poor prognosis. KRAS mutations are extremely heterogeneous from a biologic point of view, and real‐world data by mutation subtype in the era of… read more here.
Keywords: lung cancer; cancer; kras mutations; real world ... See more keywords
Effect of KRAS mutations and p53 expression on the postoperative prognosis of patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1905
Abstract: In the occurrence and development of colorectal cancer, p53 is an important regulator downstream of the MAPK signaling pathway and plays an important role in inhibiting abnormal proliferation signals generated by KRAS mutations. The purpose… read more here.
Keywords: kras mutations; p53 expression; colorectal cancer; mutations p53 ... See more keywords
Relationship between KRAS mutations and dual time point 18F-FDG PET/CT imaging in colorectal liver metastases
Sign Up to like & getrecommendations! Published in 2018 at "Abdominal Radiology"
DOI: 10.1007/s00261-018-1740-8
Abstract: PurposeTo investigate the association between metabolic parameters of dual time point 18F-FDG PET/CT imaging and Kirsten rat sarcoma (KRAS) mutation status in colorectal liver metastases (CRLM).MethodsForty-nine colorectal cancer patients with 87 liver metastatic lesions were… read more here.
Keywords: point 18f; fdg pet; 18f fdg; kras mutations ... See more keywords
Comparison of CT radiogenomic and clinical characteristics between EGFR and KRAS mutations in lung adenocarcinomas.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical radiology"
DOI: 10.1016/j.crad.2018.01.009
Abstract: AIM To compare computed tomography (CT) radiogenomic and clinical characteristics between patients with epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations in lung adenocarcinomas. MATERIALS AND METHODS This study was… read more here.
Keywords: egfr kras; radiogenomic clinical; mutations lung; lung adenocarcinomas ... See more keywords
Measuring KRAS Mutations in Circulating Tumor DNA by Droplet Digital PCR and Next-Generation Sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.07.013
Abstract: Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears prognostic value in metastatic colorectal cancer (mCRC) and… read more here.
Keywords: dna; droplet digital; cancer; next generation ... See more keywords
Oncologic Outcomes in Metastatic Colorectal Cancer with Regorafenib with FOLFIRI as a Third- or Fourth-Line Setting123
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.12.003
Abstract: BACKGROUND: To evaluate the efficacy and toxicities of regorafenib plus irinotecan, dose-escalated on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping, in previously heavily treated metastatic colorectal cancer (mCRC) and the prognostic values of… read more here.
Keywords: metastatic colorectal; colorectal cancer; egfr expression; regorafenib folfiri ... See more keywords
Imidazo Pyrimidine Compounds for the Inhibition of Oncogenic KRAS Mutations in Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00628
Abstract: This highlight outlines the development of novel imidazo-pyrimidine compounds as potent inhibitors targeting oncogenic KRAS mutations, including G12D, G12V, and G12C. The disclosure includes details on synthetic methods, biological evaluation, metabolic stability, and pharmaceutical compositions. read more here.
Keywords: oncogenic kras; inhibition oncogenic; pyrimidine compounds; imidazo pyrimidine ... See more keywords
Multiplex Digital Polymerase Chain Reaction on a Droplet Array SlipChip for Analysis of KRAS Mutations in Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c01776
Abstract: Pancreatic cancer is a terminal disease with high mortality and very poor prognosis. A sensitive and quantitative analysis of KRAS mutations in pancreatic cancer provides a tool not only to understand the biological mechanisms of… read more here.
Keywords: pancreatic cancer; mutations pancreatic; analysis; kras mutations ... See more keywords
Invasive mucinous adenocarcinoma: genetic insights into a lung cancer entity with distinct clinical behavior and genomic features
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00945-0
Abstract: Invasive mucinous adenocarcinoma (IMA) is defined by the WHO classification as a primary lung adenocarcinoma with tumor cells showing goblet cellor columnar cell-morphology (Fig. 1) with abundant intracytoplasmic mucin. Due to its distinctive clinical features,… read more here.
Keywords: smoking; lung; imas; entity ... See more keywords
Recurrent KRAS mutations are early events in the development of papillary renal neoplasm with reverse polarity
Sign Up to like & getrecommendations! Published in 2022 at "Modern Pathology"
DOI: 10.1038/s41379-022-01018-6
Abstract: We evaluated the clinicopathologic and molecular characteristics of mostly incidentally detected, small, papillary renal neoplasms with reverse polarity (PRNRP). The cohort comprised 50 PRNRP from 46 patients, divided into 2 groups. The clinically undetected ( T… read more here.
Keywords: reverse polarity; clinically undetected; prnrp; kras mutations ... See more keywords
KRAS mutations promote the intratumoral colonization of enterotoxigenic bacteroides fragilis in colorectal cancer through the regulation of the miRNA3655/SURF6/IRF7/IFNβ axis
Sign Up to like & getrecommendations! Published in 2024 at "Gut Microbes"
DOI: 10.1080/19490976.2024.2423043
Abstract: ABSTRACT KRAS mutations are associated with poor prognosis in colorectal cancer (CRC). Although the association between the gut microbiota and CRC has been extensively documented, it is unclear whether KRAS mutations can regulate the gut… read more here.
Keywords: colorectal cancer; intratumoral colonization; crc; kras mutations ... See more keywords