KRAS , NRAS , BRAF, and PIK3CA mutation rates, clinicopathological association, and their prognostic value in Iranian colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24868
Abstract: Mutations in KRAS, NRAS, BRAF, and PIK3CA genes are critical factors in clinical evaluation of colorectal cancer (CRC) development and progression. In Iran, however, the data regarding genetic profile of CRC patients is limited except… read more here.
Keywords: braf pik3ca; kras nras; pik3ca mutation; colorectal cancer ... See more keywords
KRAS and NRAS mutational analysis in plasma ctDNA from patients with metastatic colorectal cancer by real-time PCR and digital PCR
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-022-04126-6
Abstract: Mutations in the KRAS and NRAS (RAS) genes are negative predictors of response to anti-EGFR therapy in metastatic colorectal cancer (mCRC). The detection of mutations in circulating tumor DNA (ctDNA) has emerged as a less… read more here.
Keywords: analysis; metastatic colorectal; kras nras; ctdna ... See more keywords
Cetuximab in Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Ovarian Cancer Without KRAS, NRAS, or BRAF Mutations: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study
Sign Up to like & getrecommendations! Published in 2020 at "Targeted Oncology"
DOI: 10.1007/s11523-020-00753-7
Abstract: The Targeted Agent and Profiling Utilization Registry (TAPUR) Study, a phase II basket study, evaluates anti-tumor activity of commercially available targeted agents in patients with advanced cancers harboring genomic alterations known as drug targets. With… read more here.
Keywords: kras nras; cetuximab; nras braf; cancer ... See more keywords
Clinicopathological Features and Prognostic Value of KRAS/NRAS/BRAF Mutations in Colorectal Cancer Patients of Central China
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-021-2326-1
Abstract: The incidence of colorectal cancer (CRC) is increasing in China, with high mortality. Here, we aimed to evaluate the latest clinicopathological features and prognostic value of the KRAS/NRAS/BRAF mutation status in CRC patients in Central… read more here.
Keywords: kras nras; crc patients; nras braf; crc ... See more keywords
Is there any correlation among MKK4 (mitogen-activated protein kinase kinase 4) expression, clinicopathological features, and KRAS/NRAS mutation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Molecular Diagnostics"
DOI: 10.1080/14737159.2020.1784728
Abstract: ABSTRACT Background We aimed to evaluate the correlation between MKK4 expression and clinicopathological features, KRAS/NRAS mutation in colorectal cancer. Methods MKK4 expression was assessed by immunoreactivity score (IRS). Staining intensity(SI) and percentage of positively stained… read more here.
Keywords: nras mutation; kras nras; kinase; correlation ... See more keywords
KRAS, NRAS, BRAF signatures, and MMR status in colorectal cancer patients in North China
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033115
Abstract: We assessed the clinicopathological features and prognostic values of KRAS, NRAS, BRAF, and DNA mismatch repair status in colorectal cancer (CRC) to provide real-world data in developing countries. We enrolled 369 CRC patients and analyzed… read more here.
Keywords: kras nras; status colorectal; status; colorectal cancer ... See more keywords
Construction of a reference material panel for detecting KRAS/NRAS/EGFR/BRAF/MET mutations in plasma ctDNA
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2020-206745
Abstract: Background The absence of high-quality next-generation sequencing (NGS) reference material (RM) has impeded the clinical use of liquid biopsies with plasma cell-free DNA (cfDNA) in China. Objective This study aimed to develop a national RM… read more here.
Keywords: reference material; nras egfr; braf met; kras nras ... See more keywords
KRAS, NRAS and BRAF Mutations Are Highly Enriched in TRI12 Chronic Lymphocytic Leukemia and Are Associated to Shorter Time to First Treatment
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-111864
Abstract: Background Extensive sequencing data highlighted the recurrence of mutations resulting in constitutive MAP kinase signaling in chronic lymphocytic leukemia (CLL), and proposed these mutations as late drivers of CLL progression (X.S. Puente, Nature, 2015; D.A.… read more here.
Keywords: cll; tri12; kras nras; group ... See more keywords
Molecular analysis of advanced colorectal cancer in an ethnically diverse patient population at a single institution.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.4_suppl.702
Abstract: 702 Background: CRC survival and treatment response differences have been noted across racial and ethnic groups, particularly between Hispanics (HA), non-Hispanic AA (AA), and non-Hispanic Caucasian (CA). We examined if there are differences in molecular… read more here.
Keywords: patient population; analysis; kras nras; single institution ... See more keywords
Liquid biopsy for KRAS, NRAS and BRAF mutation testing in advanced colorectal cancer patients: the Argentinean experience.
Sign Up to like & getrecommendations! Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2022-0329
Abstract: Objective: To analyze the frequency of KRAS, NRAS and BRAF hotspot mutations in circulating tumor DNA (ctDNA) from patients with metastatic colorectal cancer (mCRC). Methods: Observational, descriptive and retrospective study in mCRC patients with available… read more here.
Keywords: kras nras; ras braf; colorectal cancer; liquid biopsy ... See more keywords
The Five-year KRAS, NRAS and BRAF Analysis Results and Treatment Patterns in Daily Clinical Practice in Slovenia in 1st Line Treatment of Metastatic Colorectal (mCRC) Patients with RAS Wild-type Tumour (wtRAS) – A Real- Life Data Report 2013–2018
Sign Up to like & getrecommendations! Published in 2023 at "Radiology and Oncology"
DOI: 10.2478/raon-2023-0014
Abstract: Abstract Background We preformed a Phase IV non-interventional study to assess KRAS, NRAS and BRAF status in metastatic colorectal cancer (mCRC) patients suitable for 1st line treatment and to evaluate the decisions for 1st line… read more here.
Keywords: kras nras; line; line treatment; treatment ... See more keywords