RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation.
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DOI: 10.1021/acs.jmedchem.7b00622
Abstract: The human KRAS transcript contains a G-rich 5'-UTR sequence (77% GC) harboring several G4 motifs capable to form stable RNA G-quadruplex (RG4) structures that can serve as targets for small molecules. A biotin-streptavidin pull-down assay… read more here.
Keywords: rna quadruplexes; targets small; small molecules; kras oncogene ... See more keywords