Discovery of Novel KRAS-PDEδ Inhibitors by Fragment-Based Drug Design.
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DOI: 10.1021/acs.jmedchem.8b00057
Abstract: Targeting KRAS-PDEδ protein-protein interactions with small molecules represents a promising opportunity for developing novel antitumor agents. However, current KRAS-PDEδ inhibitors are limited by poor cellular antitumor potency and the druggability of the target remains to… read more here.
Keywords: pde inhibitors; kras pde; fragment based; drug design ... See more keywords