Scaffold repurposing of fendiline: Identification of potent KRAS plasma membrane localization inhibitors.
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DOI: 10.1016/j.ejmech.2021.113381
Abstract: KRAS plays an essential role in regulating cell proliferation, differentiation, migration and survival. Mutated KRAS is a major driver of malignant transformation in multiple human cancers. We showed previously that fendiline (6) is an effective… read more here.
Keywords: membrane localization; localization inhibitors; scaffold repurposing; kras plasma ... See more keywords