Predicting the conformational variability of oncogenic GTP-bound G12D mutated KRas-4B proteins at zwitterionic model cell membranes.
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DOI: 10.1039/d1nr07622a
Abstract: KRas proteins are the largest family of mutated Ras isoforms, participating in a wide variety of cancers. Due to their importance, large effort is being carried out on drug development by small-molecule inhibitors. However, understanding… read more here.
Keywords: gtp bound; kras proteins; conformational variability; g12d mutated ... See more keywords