In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders
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DOI: 10.1021/acs.jcim.2c01479
Abstract: The KRAS switch-II pocket (SII-P) has proven to be one of the most successful tools for targeting KRAS with small molecules to date. This has been demonstrated with several KRAS(G12C)-targeting covalent inhibitors, already resulting in… read more here.
Keywords: switch pocket; water; conserved water; thr58 ... See more keywords