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Published in 2023 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2023.41.36_suppl.425082
Abstract: 425082 Background: KRAS, a mediator of signalling pathways essential for cellular growth, proliferation, and survival, is the most frequently mutated oncogene in cancer. Notably, KRAS mutations occur in ~90% of pancreatic cancers, of which ~2%…
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Keywords:
krasg12c mutation;
tumors harboring;
harboring krasg12c;
solid tumors ... See more keywords
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Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230330122000
Abstract: Adagrasib is an orally bioavailable, highly selective, small-molecule, irreversible covalent inhibitor of KRASG12C. It was approved by the US FDA on December 12, 2022, for patients with tumors harboring the KRASG12C mutation in locally advanced…
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Keywords:
krasg12c mutation;
lung cancer;
non small;
small cell ... See more keywords