Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
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DOI: 10.1101/2022.07.25.501348
Abstract: Mutations within Ras proteins represent major drivers in human cancer. In this study, we report the structure-based design, synthesis, as well as biochemical and cellular evaluation of nucleotide-based covalent inhibitors for KRasG13C, an important oncogenic… read more here.
Keywords: covalent inhibitors; nucleotide based; krasg13c covalently; based covalent ... See more keywords