The unbroken Krebs cycle. Hormonal‐like regulation and mitochondrial signaling to control mitophagy and prevent cell death
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200194
Abstract: The tricarboxylic acid (TCA) or Krebs cycle, which takes place in prokaryotic cells and in the mitochondria of eukaryotic cells, is central to life on Earth and participates in key events such as energy production… read more here.
Keywords: cycle; like regulation; cycle hormonal; hormonal like ... See more keywords
Distinctive Krebs cycle remodeling in iPSC-derived neural and mesenchymal stem cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.033
Abstract: Mitochondria play a vital role in proliferation and differentiation and their remodeling in the course of differentiation is related to the variable energy and metabolic needs of the cell. In this work, we show a… read more here.
Keywords: krebs cycle; stem; stem cells; neural mesenchymal ... See more keywords
Krebs Cycle Reborn in Macrophage Immunometabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-081619-104850
Abstract: A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types rewire metabolic pathways as a… read more here.
Keywords: krebs cycle; reborn macrophage; immunology; cycle reborn ... See more keywords
Mechanism underlying gender difference in heart disease risks and corresponding preventive measures
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Preventive Cardiology"
DOI: 10.1177/2047487317731208
Abstract: Dear Sir Heart diseases mostly are age-related disorders. Such conditions deteriorate after intense labor or in cold weather, suggesting that energy metabolism may be one of the causal factors in addition to genetic predisposition. Men… read more here.
Keywords: heart; preventive measures; heart disease; krebs cycle ... See more keywords
Ketamine exerts a protective role in a cell-based model of major depressive disorder via the inhibition of apoptosis and inflammation and activation of the Krebs cycle
Sign Up to like & getrecommendations! Published in 2019 at "Bosnian Journal of Basic Medical Sciences"
DOI: 10.17305/bjbms.2019.4222
Abstract: Major depressive disorder (MDD) is one of the most common psychiatric disorders characterized by major depressive episodes. Although great efforts have been made to develop antidepressant drugs that target the monoaminergic system, these drugs are… read more here.
Keywords: apoptosis; ketamine; group; major depressive ... See more keywords
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Oncotarget"
DOI: 10.18632/oncotarget.28273
Abstract: Loss-of-function mutations in genes encoding the Krebs cycle enzymes Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) induce accumulation of fumarate and succinate, respectively and predispose patients to hereditary cancer syndromes including the development of aggressive… read more here.
Keywords: cell carcinoma; renal cell; krebs cycle; poly adp ... See more keywords
Krebs Cycle Rewired: Driver of Atherosclerosis Progression?
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210806105246
Abstract: The tricarboxylic acid (TCA) cycle is the center of energy metabolism in eukaryotic cells and dynamically adjusted according to energy needs of cells. Macrophages are activated by inflammatory stimuli, and then two breakpoints in TCA… read more here.
Keywords: rewired driver; cycle; krebs cycle; cycle rewired ... See more keywords
The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00408
Abstract: Alternative splicing is a pervasive mechanism that molds the transcriptome to meet cell and organism needs. However, how this layer of gene expression regulation is coordinated with other aspects of the cell metabolism is still… read more here.
Keywords: cell metabolism; krebs cycle; alternative splicing; splicing programs ... See more keywords
Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells
Sign Up to like & getrecommendations! Published in 2017 at "Antioxidants"
DOI: 10.3390/antiox6010021
Abstract: Krebs cycle intermediates (KCIs) are reported to function as energy substrates in mitochondria and to exert antioxidants effects on the brain. The present study was designed to identify which KCIs are effective neuroprotective compounds against… read more here.
Keywords: reactive oxygen; oxygen species; ht22 cells; krebs cycle ... See more keywords
Mitochondrial Ultrastructure and Activity Are Differentially Regulated by Glycolysis-, Krebs Cycle-, and Microbiota-Derived Metabolites in Monocytes
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11081132
Abstract: Simple Summary Beyond their metabolic role, several metabolites are also signalling molecules, contributing to cell–cell communication. This work analyses how monocytes mitochondria differentially respond to metabolites. Abstract Several intermediate metabolites harbour cell-signalling properties, thus, it… read more here.
Keywords: cell; ultrastructure; mitochondrial ultrastructure; ultrastructure activity ... See more keywords
Robustness of the Krebs Cycle under Physiological Conditions and in Cancer: New Clues for Evaluating Metabolism-Modifying Drug Therapies
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10051199
Abstract: The Krebs cycle in cells that contain mitochondria is necessary for both energy production and anabolic processes. In given cell/condition, the Krebs cycle is dynamic but remains at a steady state. In this article, we… read more here.
Keywords: metabolism; cycle; metabolism modifying; krebs cycle ... See more keywords