Comparative anticonvulsant activity of the GABAkine KRM‐II‐81 and a deuterated analog
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DOI: 10.1002/ddr.22042
Abstract: A series of imidazodiazepines has been developed that possess reduced sedative liabilities but retain efficacy in anticonvulsant screening models. The latest of these compounds, (5‐(8‐ethynyl‐6‐(pyridin‐2‐yl)‐4H‐benzo[f]imidazole[1,5‐α][1,4]diazepin‐3‐yl) oxazole known as KRM‐II‐81) is currently awaiting advancement into the… read more here.
Keywords: comparative anticonvulsant; krm; anticonvulsant activity; anticonvulsant ... See more keywords
Hydrochloride Salt of the GABAkine KRM-II-81
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DOI: 10.1021/acsomega.2c03029
Abstract: Imidazodiazepine (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin-3-yl) oxazole or KRM-II-81) is a potentiator of GABAA receptors (a GABAkine) undergoing preparation for clinical development. KRM-II-81 is active against many seizure and pain models in rodents, where it exhibits improved pharmacological properties… read more here.
Keywords: krm; hydrochloride salt; krm hcl; salt ... See more keywords