Carcinomas assemble a filamentous CXCL12–keratin-19 coating that suppresses T cell–mediated immune attack
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119463119
Abstract: Significance Carcinomas resist immunotherapy because T cells are absent from nests of cancer cells. The chemokine/chemokine receptor system, which regulates the migration of immune cells, is a candidate for this impaired intratumoral accumulation of T… read more here.
Keywords: cancer; cancer cells; krt19; cxcl12 keratin ... See more keywords
Nuclear KRT19 is a transcriptional corepressor promoting histone deacetylation and liver tumorigenesis
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DOI: 10.1097/hep.0000000000000875
Abstract: Background and Aims: Epigenetic reprogramming and escape from terminal differentiation are poorly understood enabling characteristics of liver cancer. Keratin 19 (KRT19), classically known to form the intermediate filament cytoskeleton, is a marker of stemness and… read more here.
Keywords: cancer; liver tumorigenesis; krt19; corepressor ... See more keywords
Prognostic significance of KRT19 in Lung Squamous Cancer
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DOI: 10.7150/jca.51179
Abstract: Backgroud: Keratin 19 (KRT19) is the intermediate filament that constitutes the cytoskeleton and regulates cell-cycle and cell death. Objective: We aimed to assess whether KRT19 was involved in lung cancer development. Methods: The expression of… read more here.
Keywords: krt19; expression; lung cancer; cancer ... See more keywords