Confirmation of the role of a KRT5 mutation and successful management of skin lesions in a patient with Galli–Galli disease
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13683
Abstract: Galli–Galli disease (GGD) is a rare autosomal dominant genodermatosis, which is considered an acantholytic variant of Dowling–Degos disease (DDD). It is characterized by reticular, lentigo-like hyperpigmentation on the groins, axillae and large folds, occurring between… read more here.
Keywords: krt5; krt5 mutation; dermatology; galli ... See more keywords
KRT5 mutation regulate melanin metabolism through Notch signaling pathway between keratinocytes and melanocytes.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental dermatology"
DOI: 10.1111/exd.14761
Abstract: Dowling-Degos disease (DDD) is an autosomal dominant hereditary skin disease characterized by acquired reticular hyperpigmentation in flexural sites, and one of its causative genes is KRT5 gene. But the effect of KRT5, expressed only in… read more here.
Keywords: krt5 mutation; notch signaling; signaling pathway; keratinocytes melanocytes ... See more keywords