Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145381
Abstract: We have previously found and characterized two pairs of enhancer elements, E1 and E2, in the type II collagen alpha 1 chain (COL2A1) gene. Subsequent studies have suggested that these enhancers function differently in the… read more here.
Keywords: kruppel like; gene expression; expression; type collagen ... See more keywords
Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
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DOI: 10.1038/s41467-017-02720-9
Abstract: Kruppel-like factor 4 (Klf4) is a zinc-finger-containing protein that plays a critical role in diverse cellular physiology. While most of these functions attribute to its role as a transcription factor, it is postulated that Klf4… read more here.
Keywords: kruppel like; klf4; like factor; neurogenesis ... See more keywords
Kruppel‐like factor 4 improves obesity‐related nephropathy through increasing mitochondrial biogenesis and activities
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DOI: 10.1111/jcmm.14628
Abstract: Obesity is positively linked to multiple metabolic complications including renal diseases. Several studies have demonstrated Kruppel‐like factor 4 (KLF4) participated in renal dysfunction and structural disorders in acute kidney injuries, but whether it affected the… read more here.
Keywords: kruppel like; klf4; related nephropathy; obesity related ... See more keywords
Kruppel‐like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes
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DOI: 10.1111/jdi.13511
Abstract: Brown adipose tissue (BAT) utilizes large amounts of fuel for thermogenesis, but the mechanism by which fuel substrates are switched in response to changes in energy status is poorly understood. We have now investigated the… read more here.
Keywords: kruppel like; like factor; regulates fuel; factor regulates ... See more keywords
High expression of Kruppel-like factor 4 as a predictor of poor prognosis for cervical cancer patient response to radiotherapy
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DOI: 10.1177/1010428317710225
Abstract: Purpose: The aim of this study was to explore the associations of Kruppel-like factor 4 expression with sensitivity to radiation therapy in locally advanced cervical squamous cell carcinoma patients. Methods: The records of 117 locally… read more here.
Keywords: kruppel like; radiation therapy; factor expression; like factor ... See more keywords
Kruppel-like factor 15 is required for the cardiac adaptive response to fasting
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DOI: 10.1371/journal.pone.0192376
Abstract: Cardiac metabolism is highly adaptive in response to changes in substrate availability, as occur during fasting. This metabolic flexibility is essential to the maintenance of contractile function and is under the control of a group… read more here.
Keywords: kruppel like; response fasting; response; adaptive response ... See more keywords
Inhibition of Kruppel-like factor 7 attenuates cell proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis through nuclear factor κB and mitogen-activated protein kinase signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Animals"
DOI: 10.1538/expanim.21-0200
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease, which can lead to joint inflammation and progressive joint destruction. Kruppel-like factor 7 (KLF7) is the member of KLF family and plays an important role in multiple biological… read more here.
Keywords: cell proliferation; kruppel like; like factor; rheumatoid arthritis ... See more keywords
Kruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophy
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DOI: 10.3390/ijms19051303
Abstract: Left ventricular hypertrophy (LVH) is an independent risk factor for adverse cardiovascular events and is often present in patients with hypertension. Treatment to reduce blood pressure and regress LVH is key to improving health outcomes,… read more here.
Keywords: kruppel like; ventricular hypertrophy; hypertrophy; factor ... See more keywords
Kruppel-like Factors in Skeletal Physiology and Pathologies
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DOI: 10.3390/ijms232315174
Abstract: Kruppel-like factors (KLFs) belong to a large group of zinc finger-containing transcription factors with amino acid sequences resembling the Drosophila gap gene Krüppel. Since the first report of molecular cloning of the KLF family gene,… read more here.
Keywords: physiology pathologies; kruppel like; factors skeletal; skeletal physiology ... See more keywords
Decreased Serum Kruppel-Like Factor 7 Level is Positively Associated with Low-Density Lipoprotein Cholesterol Level in Women with Polycystic Ovary Syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2018.180908
Abstract: BACKGROUND Kruppel-like factor 7 (KLF7) is associated with type 2 diabetes and obesity; however, at present the KLF7 level in polycystic ovary syndrome (PCOS) remains unreported. METHODS In this study, serum KLF7, glucose, insulin, C-reactive… read more here.
Keywords: polycystic ovary; kruppel like; level positively; level ... See more keywords