Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Research"
DOI: 10.1080/01616412.2017.1356156
Abstract: Abstract Recently, we demonstrated that inhibition of ERK1/2 activity by SL-327 treatment blocks seizure behavior in Krushinsky-Molodkina (KM) rats, which was mediated by altering of GABA and glutamate release mechanism in the hippocampus. Basal ganglia… read more here.
Keywords: molodkina rats; system; krushinsky molodkina; substantia nigra ... See more keywords
Study of Uridine Effect on the Development of Audiogenic Tonic Seizures in Krushinsky–Molodkina Strain Rats
Sign Up to like & getrecommendations! Published in 2018 at "Doklady Biological Sciences"
DOI: 10.1134/s0012496618040014
Abstract: The latency of tonic seizure in response to loud sound (in rats of the Krushinsky–Molodkina strain with audiogenic epilepsy) had been slightly (although statistically significantly) longer after chronic uridine injections (100 mg/kg, i.p., three times… read more here.
Keywords: krushinsky molodkina; tonic seizures; molodkina strain; effect ... See more keywords
Social Behavioral Deficits in Krushinsky-Molodkina Rats, an Animal Model of Audiogenic Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12122062
Abstract: In clinical practice, epilepsy is often comorbid with the autism spectrum disorders (ASDs). This warrants a search of animal models to uncover putative overlapping neuronal mechanisms. The Krushinsky-Molodkina (KM) rat strain is one of the… read more here.
Keywords: behavioral deficits; animal model; krushinsky molodkina; epilepsy ... See more keywords