vFLIP-regulated competing endogenous RNA (ceRNA) networks targeting lytic induction for KSHV-associated malignancies.
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DOI: 10.1002/jmv.27654
Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) causes life-long latent infection and malignancies, including Kaposi sarcoma (KS) commonly found in AIDS patients. Lytic replication can be induced to kill tumor cells harboring latent KSHV, through viral cytopathic effects… read more here.
Keywords: associated malignancies; cerna networks; mir; kshv associated ... See more keywords
CXCL1 confers a survival advantage in Kaposi's sarcoma‐associated herpesvirus‐infected human endothelial cells through STAT3 phosphorylation
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DOI: 10.1002/jmv.28020
Abstract: Many cytokines produced by Kaposi's sarcoma‐associated herpesvirus (KSHV)‐infected cells have been shown to participate in the pathogenesis of KSHV. Determination of the exact role of cytokines in Kaposi's sarcoma (KS) pathogenesis is limited, however, by… read more here.
Keywords: kshv infected; cxcl1; endothelial cells; kshv ... See more keywords
Seroprevalence of Kaposi's sarcoma‐associated herpesvirus and risk factors in Jiuquan area, China
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DOI: 10.1002/jmv.28045
Abstract: The seroprevalence of Kaposi's sarcoma‐associated herpesvirus (KSHV) is high in Xinjiang, China. But the seroprevalence of KSHV and risk factors are still unknown in Gansu which is adjacent to Xinjiang. Six hundred and seventy‐eight serum… read more here.
Keywords: seroprevalence; jiuquan area; kshv; risk ... See more keywords
ORF45, a multifunctional immediate early and tegument protein of KSHV
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DOI: 10.1002/jmv.28659
Abstract: Kaposi sarcoma‐associated herpesvirus (KSHV) is the etiological agent of several human diseases, including Kaposi sarcoma, primary effusion lymphoma, and a subset of multicentric Castleman's disease. KSHV uses its gene products to manipulate many aspects of… read more here.
Keywords: tegument protein; multifunctional immediate; immediate early; kshv ... See more keywords
An endothelial cell line infected by Kaposi’s sarcoma–associated herpes virus (KSHV) allows the investigation of Kaposi’s sarcoma and the validation of novel viral inhibitors in vitro and in vivo
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DOI: 10.1007/s00109-018-01733-1
Abstract: Kaposi’s sarcoma–associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma (KS), a tumor of endothelial origin predominantly affecting immunosuppressed individuals. Up to date, vaccines and targeted therapies are not available. Screening and identification of… read more here.
Keywords: cell line; kaposi sarcoma; kshv; endothelial cell ... See more keywords
Environmental determinants of Kaposi's sarcoma-associated herpesvirus (KSHV) transmission in rural Uganda (ENDKU study): Contributions to research on KSHV infection and reactivation in African children; A longitudinal cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer epidemiology"
DOI: 10.1016/j.canep.2022.102154
Abstract: BACKGROUND The Environmental Determinants of KSHV transmission in rural Uganda (ENDKU) study began enrollment in February 2020 with the purpose of defining the relationship between malaria, primarily caused by Plasmodium falciparum in sub-Saharan Africa, and… read more here.
Keywords: endku study; study; cohort; kshv ... See more keywords
DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV
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DOI: 10.1016/j.cell.2019.07.035
Abstract: Summary Assembly of Kaposi’s sarcoma-associated herpesvirus (KSHV) begins at a bacteriophage-like portal complex that nucleates formation of an icosahedral capsid with capsid-associated tegument complexes (CATCs) and facilitates translocation of an ∼150-kb dsDNA genome, followed by… read more here.
Keywords: associated tegument; kshv; herpesvirus kshv; capsid ... See more keywords
Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
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DOI: 10.1016/j.celrep.2020.108249
Abstract: Summary Kaposi’s sarcoma herpesvirus (KSHV) is an oncogenic human virus and the leading cause of mortality in HIV infection. KSHV reactivation from latent- to lytic-stage infection initiates a cascade of viral gene expression. Here we… read more here.
Keywords: kshv; analysis; infection; lytic kshv ... See more keywords
Kaposi's sarcoma herpesvirus-induced endothelial cell reprogramming supports viral persistence and contributes to Kaposi's sarcoma tumorigenesis.
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DOI: 10.1016/j.coviro.2017.09.002
Abstract: Kaposi's sarcoma (KS) is an endothelial tumor causally linked to Kaposi's sarcoma herpesvirus (KSHV) infection. At early stages of KS, inflammation and aberrant neoangiogenesis are predominant, while at late stages the disease is characterized by… read more here.
Keywords: kaposi sarcoma; kshv; sarcoma herpesvirus; endothelial cell ... See more keywords
Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.
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DOI: 10.1016/j.virol.2019.10.002
Abstract: KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic features of a KICS patient over time.… read more here.
Keywords: sarcoma; kaposi sarcoma; kshv; associated herpesvirus ... See more keywords
Comparative analysis of the viral interferon regulatory factors of KSHV for their requisite for virus production and inhibition of the type I interferon pathway.
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DOI: 10.1016/j.virol.2019.12.011
Abstract: Unique among human viruses, Kaposi's sarcoma-associated herpesvirus (KSHV) encodes several homologs of cellular interferon regulatory factors (vIRFs). Since KSHV expresses multiple factors that can inhibit interferon (IFN) signaling to promote virus production, it is still… read more here.
Keywords: production; kshv; interferon; production inhibition ... See more keywords