Environmental risk factors and genetic markers of Kaposi's sarcoma‐associated herpesvirus infection among Uygur population in Xinjiang, China
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27600
Abstract: Kaposi sarcoma‐associated herpesvirus (KSHV) is endemic in Xinjiang, China. Determinants of KSHV seropositivity among high‐risk groups are not well understood. We seek to identify genetic and environmental predisposing factors for KSHV infection among Uygurs in… read more here.
Keywords: infection among; xinjiang china; kshv infection; infection ... See more keywords
Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.108249
Abstract: Summary Kaposi’s sarcoma herpesvirus (KSHV) is an oncogenic human virus and the leading cause of mortality in HIV infection. KSHV reactivation from latent- to lytic-stage infection initiates a cascade of viral gene expression. Here we… read more here.
Keywords: kshv; analysis; infection; lytic kshv ... See more keywords
Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab215
Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) expresses miRNAs during latency. However, regulation of viral miRNAs remains largely unknown. Our prior studies demonstrated that MCPIP1 regulates KSHV miRNA biogenesis by degrading most KSHV pre-miRNAs through its RNase activity.… read more here.
Keywords: pre mirnas; kshv infection; viral mirnas; infection ... See more keywords
Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adg1778
Abstract: Kaposi’s sarcoma–associated herpesvirus (KSHV) has been implicated in the pathogenesis of Kaposi’s sarcoma (KS) and other malignancies. The cellular origin of KS has been suggested to be either mesenchymal stem cells (MSCs) or endothelial cells.… read more here.
Keywords: kshv infection; receptor kshv; mesenchymal stem; macropinocytosis ... See more keywords
Human Immunodeficiency Virus-Associated Exosomes Promote Kaposi’s Sarcoma-Associated Herpesvirus Infection via the Epidermal Growth Factor Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01782-19
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causal agent for Kaposi’s sarcoma (KS), the most common malignancy in HIV/AIDS patients. Oral transmission through saliva is considered the most common route for spreading the virus among HIV/AIDS… read more here.
Keywords: hiv associated; kaposi sarcoma; infection; kshv infection ... See more keywords
Mast Cell Activation and KSHV Infection in Kaposi Sarcoma
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DOI: 10.1158/1078-0432.ccr-18-0873
Abstract: Purpose: Kaposi sarcoma (KS) is a vascular tumor initiated by infection of endothelial cells (ECs) with KS–associated herpesvirus (KSHV). KS is dependent on sustained proinflammatory signals provided by intralesional leukocytes and continued infection of new… read more here.
Keywords: kaposi sarcoma; kshv; mast; infection ... See more keywords
IL-21 signaling promotes the establishment of KSHV infection in human tonsil lymphocytes by increasing differentiation and targeting of plasma cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1010274
Abstract: Introduction Factors influencing Kaposi’s sarcoma-associated herpesvirus (KSHV) transmission and the early stages of KSHV infection in the human immune system remain poorly characterized. KSHV is known to extensively manipulate the host immune system and the… read more here.
Keywords: kshv infection; cell; infection; plasma cells ... See more keywords
Arachidonic Acid Derived Lipid Mediators Influence Kaposi’s Sarcoma-Associated Herpesvirus Infection and Pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.00358
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) infection, particularly latent infection is often associated with inflammation. The arachidonic acid pathway, the home of several inflammation and resolution associated lipid mediators, is widely altered upon viral infections. Several in… read more here.
Keywords: lipid mediators; infection; pathogenesis; arachidonic acid ... See more keywords
Host-Level Susceptibility and IRF1 Expression Influence the Ability of IFN-γ to Inhibit KSHV Infection in B Lymphocytes
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14102295
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with vascular endothelial cell tumor, Kaposi’s sarcoma (KS) and lymphoproliferative disorder, multicentric Castleman’s disease (MCD), primary effusion lymphoma (PEL) and KSHV inflammatory cytokine syndrome (KICS). Dysregulation of proinflammatory cytokines… read more here.
Keywords: kshv infection; susceptibility irf1; infection; level susceptibility ... See more keywords