KSHV RTA Induces Degradation of the Host Transcription Repressor ID2 To Promote the Viral Lytic Cycle
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DOI: 10.1128/jvi.00101-22
Abstract: In addition to its transcription regulatory role, RTA is also known to have an E3 ubiquitin ligase activity, which RTA utilizes for inducing protein degradation. However, it is still largely unknown what host factors are… read more here.
Keywords: lytic cycle; kshv lytic; transcription; rta ... See more keywords
KSHV lytic proteins K-RTA and K8 bind to cellular and viral chromatin to modulate gene expression
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DOI: 10.1371/journal.pone.0215394
Abstract: The oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) has two distinct life cycles with lifelong latent/non-productive and a sporadic lytic-reactivating/productive phases in the infected immune compromised human hosts. The virus reactivates from latency in response to various… read more here.
Keywords: dna; chromatin; rta; kshv lytic ... See more keywords
The SUMO E3 ligase activity of ORF45 determines KSHV lytic replication
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DOI: 10.1371/journal.ppat.1010504
Abstract: RSK1, an essential cellular kinase for Kaposi’s sarcoma-associated herpesvirus (KSHV) replication, is highly phosphorylated and SUMOylated during KSHV lytic cycle, which determine the substrate phosphorylation and specificity of RSK1, respectively. However, the SUMO E3 ligase… read more here.
Keywords: rsk1; kshv lytic; replication; ligase ... See more keywords
Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition
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DOI: 10.1371/journal.ppat.1011103
Abstract: Primary effusion lymphoma (PEL), a rare aggressive B-cell lymphoma in immunosuppressed patients, is etiologically associated with oncogenic γ-herpesvirus infection. Chemotherapy is commonly used to treat PEL but usually results in poor prognosis and survival; thus,… read more here.
Keywords: inhibition; lytic replication; kshv lytic; effusion lymphoma ... See more keywords
Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1
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DOI: 10.3390/v11010008
Abstract: Previous studies have indicated that cytotoxic treatments may induce or not activate viral lytic cycle activation in cancer cells latently infected by Kaposi's sarcoma-associated herpesvirus (KSHV). To investigate the molecular mechanisms responsible for such an… read more here.
Keywords: p62 sqstm1; kshv lytic; p62; lytic cycle ... See more keywords