Drug-Excipient Interactions: Effect on Molecular Mobility and Physical Stability of Ketoconazole-Organic Acid Coamorphous Systems.
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DOI: 10.1021/acs.molpharmaceut.7b00932
Abstract: The use of excipients other than polymers for enhancing the physical stability of amorphous active pharmaceutical ingredients (APIs) has largely been unexplored. We investigated several organic acids (oxalic, tartaric, citric, and succinic acid) for the… read more here.
Keywords: ktz acid; mobility; molecular mobility; stability ... See more keywords