Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab743
Abstract: Abstract Multiple pathways mediate the repair of DNA double-strand breaks (DSBs), with numerous mechanisms responsible for driving choice between the pathways. Previously, we reported that mutating five putative phosphorylation sites on the non-homologous end joining… read more here.
Keywords: hepatocellular carcinoma; repair spontaneous; ku70; phosphorylation sites ... See more keywords
Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab980
Abstract: Abstract Canonical non-homologous end-joining (cNHEJ) is the prominent mammalian DNA double-strand breaks (DSBs) repair pathway operative throughout the cell cycle. Phosphorylation of Ku70 at ser27-ser33 (pKu70) is induced by DNA DSBs and has been shown… read more here.
Keywords: dna damage; ku70; dna; induced dna ... See more keywords
Abstract 5847: SIRT1 protects against radiation-induced lung injury via de-acetylating the Ku70 and P65
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5847
Abstract: Radiation-induced lung injury (RILI) is a common and serious complication in the radiation therapy of thoracic cancer, which significantly restricts the radiation doses of tumor. The prevention and treatment of RILI have long been clinical… read more here.
Keywords: sirt1; ku70; radiation induced; rili ... See more keywords
CIRKIL Exacerbates Cardiac Ischemia/Reperfusion Injury by Interacting With Ku70
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.318992
Abstract: Supplemental Digital Content is available in the text. Background: Ku70 participates in several pathological processes through mediating repair of DNA double-strand breaks. Our previous study has identified a highly conserved long noncoding RNA cardiac ischemia… read more here.
Keywords: injury; cirkil; ku70; ischemia reperfusion ... See more keywords
Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors
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DOI: 10.3390/ijms23062908
Abstract: The interaction of HIV-1 integrase and the cellular Ku70 protein is necessary for HIV replication due to its positive effect on post-integration DNA repair. We have previously described in detail the Ku70 binding site within… read more here.
Keywords: interaction; integrase; search inhibitors; hiv integrase ... See more keywords
Ku70 N-terminal lysines acetylation/deacetylation is required for radiation-induced DNA-double strand breaks repair.
Sign Up to like & getrecommendations! Published in 2018 at "Neoplasma"
DOI: 10.4149/neo_2018_171020n673
Abstract: Ku70 protein in hetero-trimeric complex with Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) represents a critical component of the nonhomologous-end-joining (NHEJ), the major machinery of DSBs repair in mammalian cells. It has been previously… read more here.
Keywords: acetylation deacetylation; acetylation; ku70; dna ... See more keywords