Inhibition of KU70 and KU80 by CRISPR interference, not NgAgo interference, increases the efficiency of homologous recombination in pig fetal fibroblasts
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DOI: 10.1016/s2095-3119(18)62150-1
Abstract: Abstract Non-homologous end-joining (NHEJ) is a predominant pathway for the repair of DNA double-strand breaks (DSB). It inhibits the efficiency of homologous recombination (HR) by competing for DSB targets. To improve the efficiency of HR,… read more here.
Keywords: efficiency homologous; ku70 ku80; homologous recombination; interference ... See more keywords
Abstract 3218: Maternal embryonic leucine zipper kinase (MELK) confers radioresistance in triple-negative breast cancers (TNBC) through a nonhomologous end joining (NHEJ)-mediated pathway
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DOI: 10.1158/1538-7445.am2018-3218
Abstract: Background: Increased rates of locoregional recurrence have been observed in TNBC despite the use of radiation (RT); therefore, approaches that result in radiosensitizaton in TNBC may improve clinical outcomes. Despite some controversy as to the… read more here.
Keywords: nhej mediated; melk; kinase; melk confers ... See more keywords