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   Articles with "kunitz type" as a keyword



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Engineering varied serine protease inhibitors by converting P1 site of BF9, a weakly active Kunitz-type animal toxin.

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recommendations! Published in 2018 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2018.08.178

Abstract: Although there were a lot of weakly active animal toxins in the venoms, their values and applications are still mysterious, such as BF9, which is a Kunitz-type toxin isolated from the venom of the elapid… read more here.

Keywords: kunitz type; weakly active; animal; bf9 ... See more keywords
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Isolation and partial structural characterization of new Kunitz-type trypsin inhibitors from the pike cestode Triaenophorus nodulosus.

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recommendations! Published in 2019 at "Molecular and biochemical parasitology"

DOI: 10.1016/j.molbiopara.2019.111217

Abstract: The inhibitors produced by the parasitic worms successfully protect them from the host's proteases and are supposed to underlie the host-parasite specificity. Our previous study has shown that the extracts from the pike tapeworm Triaenophorus… read more here.

Keywords: kunitz type; triaenophorus nodulosus; trypsin; type ... See more keywords
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Purification and characterization of an anti‐hemorrhagic protein from Naja naja (Indian cobra) venom

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recommendations! Published in 2017 at "Toxicon"

DOI: 10.1016/j.toxicon.2017.10.019

Abstract: ABSTRACT Snake venom Kunitz‐type proteins are well known to inhibit serine proteases but a few studies have also shown matrix metalloproteases (MMPs) inhibition. In view of the fact that MMPs and snake venom metalloproteases (SVMPs)… read more here.

Keywords: kunitz type; carinatus venom; anti hemorrhagic; venom ... See more keywords
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The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development.

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recommendations! Published in 2021 at "Developmental biology"

DOI: 10.1016/j.ydbio.2021.03.017

Abstract: We have previously shown that the Kunitz-type serine protease inhibitor Spint1a, also named Hai1a, is required in the zebrafish embryonic epidermis to restrict the activity of the type II transmembrane serine protease (TTSP) Matriptase1a/St14a, thereby… read more here.

Keywords: kunitz type; hatching gland; migration; gland ... See more keywords
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Kunitz type protease inhibitor from the canine tapeworm as a potential therapeutic for melanoma

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-52609-4

Abstract: Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have… read more here.

Keywords: melanoma; kunitz type; protease inhibitor; protease ... See more keywords
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TcTI, a Kunitz-type trypsin inhibitor from cocoa associated with defense against pathogens

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recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-021-04700-y

Abstract: Protease inhibitors (PIs) are important biotechnological tools of interest in agriculture. Usually they are the first proteins to be activated in plant-induced resistance against pathogens. Therefore, the aim of this study was to characterize a… read more here.

Keywords: trypsin; inhibitory activity; trypsin inhibitor; inhibitor ... See more keywords
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WPK5, a Novel Kunitz-Type Peptide from the Leech Whitmania pigra Inhibiting Factor XIa, and Its Loop-Replaced Mutant to Improve Potency

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recommendations! Published in 2021 at "Biomedicines"

DOI: 10.3390/biomedicines9121745

Abstract: Kunitz-type proteins or peptides have been found in many blood-sucking animals, but the identity of them in leeches remained elusive. In the present study, five Kunitz-type peptides named WPK1-WPK5 were identified from the leech Whitmania… read more here.

Keywords: loop; wpk5; potency; kunitz type ... See more keywords
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Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson’s Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23095115

Abstract: Parkinson’s disease (PD) is a socially significant disease, during the development of which oxidative stress and inflammation play a significant role. Here, we studied the neuroprotective effects of four Kunitz-type peptides from Heteractis crispa and… read more here.

Keywords: type peptides; kunitz type; sea anemones; disease ... See more keywords
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Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells

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recommendations! Published in 2023 at "Marine Drugs"

DOI: 10.3390/md21030192

Abstract: Purinergic P2X7 receptors (P2X7) have now been proven to play an important role and represent an important therapeutic target in many pathological conditions including neurodegeneration. Here, we investigated the impact of peptides on purinergic signaling… read more here.

Keywords: type peptides; receptor; neuro cells; kunitz type ... See more keywords