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   Articles with "kv1" as a keyword



Characterization of endogenous Kv1.3 channel isoforms in T cells

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recommendations! Published in 2022 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30984

Abstract: Voltage‐dependent potassium channel Kv1.3 plays a key role on T‐cell activation; however, lack of reliable antibodies has prevented its accurate detection under endogenous circumstances. To overcome this limitation, we created a Jurkat T‐cell line with… read more here.

Keywords: endogenous kv1; channel isoforms; kv1; kv1 channel ... See more keywords

Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels

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recommendations! Published in 2017 at "Molecular Neurobiology"

DOI: 10.1007/s12035-017-0437-2

Abstract: Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds… read more here.

Keywords: kv1; modulation; propofol; kv1 g329t ... See more keywords

Functional role of Kv1.1 and Kv1.3 channels in the neoplastic progression steps of three cancer cell lines, elucidated by scorpion peptides.

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recommendations! Published in 2018 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2018.01.144

Abstract: Voltage-gated potassium (Kv) channels are known to play a pivotal role in the progression of various cancer types and considered as new targets for designing anti-cancer therapy. However, the fact that many Kv channels are… read more here.

Keywords: kv1; kv1 kv1; cell lines; kv1 channels ... See more keywords

ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents

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recommendations! Published in 2019 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2019.04.012

Abstract: Background ADAM22 and ADAM23 are transmembrane proteins that bind the secreted synaptic protein LGI1 and associate with Kv1.1/Kv1.4 potassium channels. However, the roles of these proteins in regulated voltage-gated potassium currents are poorly understood. Methods… read more here.

Keywords: kv1; kv1 kv1; kv1 currents; lgi1 ... See more keywords

Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel KV1.3.

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recommendations! Published in 2022 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.2c00436

Abstract: Upregulation of the voltage-gated potassium channel KV1.3 is implicated in a range of autoimmune and neuroinflammatory diseases, including rheumatoid arthritis, psoriasis, multiple sclerosis, and type I diabetes. Understanding the expression, localization, and trafficking of KV1.3… read more here.

Keywords: cy5 hstx1; kv1 kv1; hstx1 r14a; kv1 ... See more keywords

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics

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recommendations! Published in 2023 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.2c01237

Abstract: Peptide toxins that adopt the ShK fold can inhibit the voltage-gated potassium channel KV1.3 with IC50 values in the pM range and are therefore potential leads for drugs targeting autoimmune and neuroinflammatory diseases. Nuclear magnetic… read more here.

Keywords: gated potassium; voltage gated; kv1; channel kv1 ... See more keywords

Detection of Voltage-Gated Potassium Channels 1.3 via Immuno-PET Visualizes Rheumatoid Arthritis.

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recommendations! Published in 2025 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.5c00357

Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory condition affecting approximately 1% of the global population, yet current diagnostic tools for early-stage RA lack sensitivity and fail to identify optimal treatment candidates. Voltage-gated potassium channel 1.3… read more here.

Keywords: kv1; gated potassium; voltage gated; rheumatoid arthritis ... See more keywords

Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3

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recommendations! Published in 2021 at "Cell Discovery"

DOI: 10.1038/s41421-021-00269-y

Abstract: Dear Editor, Voltage-gated potassium channels (KV) play vital roles in electrically excitable and non-excitable cells. They usually open with membrane depolarization and allow the flow of K ions. Ion flow through these channels is curtailed… read more here.

Keywords: kv1; potassium; supplementary fig; channel ... See more keywords
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KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-94015-9

Abstract: The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis. The regulatory subunit KCNE4 acts as an ancillary peptide of Kv1.3, modulates K+ currents and controls… read more here.

Keywords: kv1; related leukocyte; kv1 related; physiology ... See more keywords

Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2118240119

Abstract: Significance Despite decades of research on adult neurogenesis, little is known about the role of bioelectric signaling in this process. In this study, we describe how a voltage-gated potassium channel, Kv1.1, supports adult neurogenesis by… read more here.

Keywords: adult; neural stem; adult neurogenesis; kv1 ... See more keywords

A conifer metabolite corrects episodic ataxia type 1 by voltage sensor-mediated ligand activation of Kv1.1

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2411816122

Abstract: Significance Episodic ataxia type 1 (EA1) is a movement disorder caused by sequence variants in the KCNA1 gene, which encodes the Kv1.1 potassium channel. Current therapies for EA1 do not directly rescue function of the… read more here.

Keywords: kv1; ataxia type; voltage; episodic ataxia ... See more keywords