Characterization of endogenous Kv1.3 channel isoforms in T cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30984
Abstract: Voltage‐dependent potassium channel Kv1.3 plays a key role on T‐cell activation; however, lack of reliable antibodies has prevented its accurate detection under endogenous circumstances. To overcome this limitation, we created a Jurkat T‐cell line with… read more here.
Keywords: endogenous kv1; channel isoforms; kv1; kv1 channel ... See more keywords
Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0437-2
Abstract: Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds… read more here.
Keywords: kv1; modulation; propofol; kv1 g329t ... See more keywords
Functional role of Kv1.1 and Kv1.3 channels in the neoplastic progression steps of three cancer cell lines, elucidated by scorpion peptides.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.01.144
Abstract: Voltage-gated potassium (Kv) channels are known to play a pivotal role in the progression of various cancer types and considered as new targets for designing anti-cancer therapy. However, the fact that many Kv channels are… read more here.
Keywords: kv1; kv1 kv1; cell lines; kv1 channels ... See more keywords
ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.04.012
Abstract: Background ADAM22 and ADAM23 are transmembrane proteins that bind the secreted synaptic protein LGI1 and associate with Kv1.1/Kv1.4 potassium channels. However, the roles of these proteins in regulated voltage-gated potassium currents are poorly understood. Methods… read more here.
Keywords: kv1; kv1 kv1; kv1 currents; lgi1 ... See more keywords
Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel KV1.3.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00436
Abstract: Upregulation of the voltage-gated potassium channel KV1.3 is implicated in a range of autoimmune and neuroinflammatory diseases, including rheumatoid arthritis, psoriasis, multiple sclerosis, and type I diabetes. Understanding the expression, localization, and trafficking of KV1.3… read more here.
Keywords: cy5 hstx1; kv1 kv1; hstx1 r14a; kv1 ... See more keywords
Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01237
Abstract: Peptide toxins that adopt the ShK fold can inhibit the voltage-gated potassium channel KV1.3 with IC50 values in the pM range and are therefore potential leads for drugs targeting autoimmune and neuroinflammatory diseases. Nuclear magnetic… read more here.
Keywords: gated potassium; voltage gated; kv1; channel kv1 ... See more keywords
Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3
Sign Up to like & getrecommendations! Published in 2021 at "Cell Discovery"
DOI: 10.1038/s41421-021-00269-y
Abstract: Dear Editor, Voltage-gated potassium channels (KV) play vital roles in electrically excitable and non-excitable cells. They usually open with membrane depolarization and allow the flow of K ions. Ion flow through these channels is curtailed… read more here.
Keywords: kv1; potassium; supplementary fig; channel ... See more keywords
KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology
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DOI: 10.1038/s41598-021-94015-9
Abstract: The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis. The regulatory subunit KCNE4 acts as an ancillary peptide of Kv1.3, modulates K+ currents and controls… read more here.
Keywords: kv1; related leukocyte; kv1 related; physiology ... See more keywords
Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118240119
Abstract: Significance Despite decades of research on adult neurogenesis, little is known about the role of bioelectric signaling in this process. In this study, we describe how a voltage-gated potassium channel, Kv1.1, supports adult neurogenesis by… read more here.
Keywords: adult; neural stem; adult neurogenesis; kv1 ... See more keywords
Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2021.2018597
Abstract: ABSTRACT Background The objective of the present work was to study the anti-hypertensive effect of allisartan on blood pressure (BP) and in facilitating left ventricular remodeling through voltage-gated potassium channels (Kv) 1.5 channels. Methods A… read more here.
Keywords: treatment group; hypertension; kv1; group ... See more keywords
Takotsubo syndrome is a coronary microvascular disease: experimental evidence.
Sign Up to like & getrecommendations! Published in 2023 at "European heart journal"
DOI: 10.1093/eurheartj/ehad274
Abstract: BACKGROUND AND AIMS Takotsubo syndrome (TTS) is a conundrum without consensus about the cause. In a murine model of coronary microvascular dysfunction (CMD), abnormalities in myocardial perfusion played a key role in the development of… read more here.
Keywords: takotsubo syndrome; apex base; kv1; tac ... See more keywords