LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory
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DOI: 10.1093/brain/awy253
Abstract: Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), which interacts with voltage-gated potassium channels Kv1.1, and the postsynaptic… read more here.
Keywords: kv1 ampa; ampa receptors; lgi1; plasticity ... See more keywords