Characterization of endogenous Kv1.3 channel isoforms in T cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30984
Abstract: Voltage‐dependent potassium channel Kv1.3 plays a key role on T‐cell activation; however, lack of reliable antibodies has prevented its accurate detection under endogenous circumstances. To overcome this limitation, we created a Jurkat T‐cell line with… read more here.
Keywords: endogenous kv1; channel isoforms; kv1; kv1 channel ... See more keywords
Alleviating airway inflammation by inhibiting ERK‐NF‐&kgr;B signaling pathway by blocking Kv1.3 channels
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.07.009
Abstract: &NA; Allergic asthma is a chronic inflammatory disease of the airways. T lymphocytes play an important role in the pathogenesis of asthma. The voltage‐gated Kv1.3 potassium channel is a target for the preferential inhibition of… read more here.
Keywords: asthmatic mice; kgr; airway inflammation; pap ... See more keywords
Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: Evidence of diversity in beta-defensin-potassium channel interactions
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.08.005
Abstract: &NA; Recent reports have identified defensins as a new type of potassium channel inhibitors; differential binding mechanisms of human &bgr;‐defensins hBD1 and hBD2 point to complex interactions between human &bgr;‐defensins and potassium channels. We investigated… read more here.
Keywords: potassium channels; potassium channel; beta; channel ... See more keywords
Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106112
Abstract: Emerging data have demonstrated the critical roles of potassium efflux in the innate immune system. However, the role of potassium efflux in TLR3/4 activation and type I interferon (IFN) responses are not well elucidated. In… read more here.
Keywords: kv1 channel; ifn; activation; inhibition kv1 ... See more keywords
A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation
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DOI: 10.1186/s12974-017-0906-6
Abstract: BackgroundKv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the molecular and cellular mechanisms regulated by Kv1.3 channels are poorly defined.MethodsWe… read more here.
Keywords: kv1; lps induced; pharmacology; shk 223 ... See more keywords
Rational Design and Synthesis of 3-Morpholine Linked Aromatic-Imino-1H-Indoles as Novel Kv1.5 Channel Inhibitors Sharing Vasodilation Effects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.805594
Abstract: Atrial fibrillation (AF) is the most common clinical sustained arrhythmia; clinical therapeutic drugs have low atrial selectivity and might cause more severe ventricle arrhythmias while stopping AF. As an anti-AF drug target with high selectivity… read more here.
Keywords: linked aromatic; vasodilation; kv1 channel; drug ... See more keywords
GFP–Margatoxin, a Genetically Encoded Fluorescent Ligand to Probe Affinity of Kv1.3 Channel Blockers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031724
Abstract: Peptide pore blockers and their fluorescent derivatives are useful molecular probes to study the structure and functions of the voltage-gated potassium Kv1.3 channel, which is considered as a pharmacological target in the treatment of autoimmune… read more here.
Keywords: gfp mgtx; kv1; kv1 channel; fluorescent ligand ... See more keywords
Clinical and Functional Study of a De Novo Variant in the PVP Motif of Kv1.1 Channel Associated with Epilepsy, Developmental Delay and Ataxia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158079
Abstract: Mutations in the KCNA1 gene, encoding the voltage-gated potassium channel Kv1.1, have been associated with a spectrum of neurological phenotypes, including episodic ataxia type 1 and developmental and epileptic encephalopathy. We have recently identified a… read more here.
Keywords: channel; developmental delay; kv1; kv1 channel ... See more keywords
Recombinant Expression in Pichia pastoris System of Three Potent Kv1.3 Channel Blockers: Vm24, Anuroctoxin, and Ts6
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8111215
Abstract: The Kv1.3 channel has become a therapeutic target for the treatment of various diseases. Several Kv1.3 channel blockers have been characterized from scorpion venom; however, extensive studies require amounts of toxin that cannot be readily… read more here.
Keywords: system; channel blockers; expression; kv1 channel ... See more keywords
Combining mKate2-Kv1.3 Channel and Atto488-Hongotoxin for the Studies of Peptide Pore Blockers on Living Eukaryotic Cells
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14120858
Abstract: The voltage-gated potassium Kv1.3 channel is an essential component of vital cellular processes which is also involved in the pathogenesis of some autoimmune, neuroinflammatory and oncological diseases. Pore blockers of the Kv1.3 channel are considered… read more here.
Keywords: pore blockers; combining mkate2; kv1 channel; channel ... See more keywords