Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of KV10.1 Pore Blockers
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DOI: 10.3390/ijms22168999
Abstract: The KV10.1 voltage-gated potassium channel is highly expressed in 70% of tumors, and thus represents a promising target for anticancer drug discovery. However, only a few ligands are known to inhibit KV10.1, and almost all… read more here.
Keywords: kv10; molecular dynamics; kv10 pore; dynamics derived ... See more keywords