Distinct cellular expression and subcellular localization of Kv2 voltage‐gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25575
Abstract: The distinct organization of Kv2 voltage‐gated potassium channels on and near the cell body of brain neurons enables their regulation of action potentials and specialized membrane contact sites. Somatosensory neurons have a pseudounipolar morphology and… read more here.
Keywords: drg neurons; kv2 voltage; kv2; subcellular localization ... See more keywords
A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers
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DOI: 10.1101/2024.01.31.578214
Abstract: KvS proteins are voltage-gated potassium channel subunits that form functional channels when assembled into heteromers with Kv2.1 (KCNB1) or Kv2.2 (KCNB2). Mammals have 10 KvS subunits: Kv5.1 (KCNF1), Kv6.1 (KCNG1), Kv6.2 (KCNG2), Kv6.3 (KCNG3), Kv6.4… read more here.
Keywords: kv2; heteromers kv2; kvs heteromers; kvs subunits ... See more keywords
A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel activation, deactivation and inactivation
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2024.1438101
Abstract: KCNB1, on human chromosome 20q13.3, encodes the alpha subunit of the Kv2.1 voltage gated potassium channel. Kv2.1 is ubiquitously expressed throughout the brain and is critical in controlling neuronal excitability, including in the hippocampus and… read more here.
Keywords: kv2; channel activation; autism; potassium channel ... See more keywords