The expression and activity of KV3.4 channel subunits are precociously upregulated in astrocytes exposed to Aβ oligomers and in astrocytes of Alzheimer's disease Tg2576 mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.03.008
Abstract: Astrocyte dysfunction emerges early in Alzheimer's disease (AD) and may contribute to its pathology and progression. Recently, the voltage gated potassium channel KV3.4 subunit, which underlies the fast-inactivating K+ currents, has been recognized to be… read more here.
Keywords: tg2576 mice; expression; channel subunits; kv3 ... See more keywords
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22003-8
Abstract: Mutations in KCNC3, which encodes the Kv3.3 potassium channel, cause degeneration of the cerebellum, but exactly how the activity of an ion channel is linked to the survival of cerebellar neurons is not understood. Here,… read more here.
Keywords: kv3 potassium; binding kinase; tank binding; kv3 ... See more keywords
Kv3 Channels Contribute to the Excitability of Subpopulations of Spinal Cord Neurons in Lamina VII
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0510-21.2021
Abstract: Abstract Autonomic parasympathetic preganglionic neurons (PGNs) drive contraction of the bladder during micturition but remain quiescent during bladder filling. This quiescence is postulated to be because of recurrent inhibition of PGN by fast-firing adjoining interneurons.… read more here.
Keywords: kv3; pgn; fast firing; lamina vii ... See more keywords
Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00344
Abstract: The development of neuroprotective and repair strategies for treating progressive multiple sclerosis (MS) requires new insights into axonal injury. 4-aminopyridine (4-AP), a blocker of voltage-gated K+ (Kv) channels, is used in symptomatic treatment of progressive… read more here.
Keywords: inflammatory demyelinaton; demyelinaton axon; suppression inflammatory; degeneration inhibiting ... See more keywords
First Evidence of Kv3.1b Potassium Channel Subtype Expression during Neuronal Serotonergic 1C11 Cell Line Development
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21197175
Abstract: Kv3.1 channel is abundantly expressed in neurons and its dysfunction causes sleep loss, neurodegenerative diseases and depression. Fluoxetine, a serotonin selective reuptake inhibitor commonly used to treat depression, acts also on Kv3.1. To define the… read more here.
Keywords: potassium; cell line; kv3; cell ... See more keywords