K+ channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Pain"
DOI: 10.1002/ejp.2038
Abstract: Kv4 channels are key components controlling neuronal excitability at membrane potentials below action potential thresholds. It remains elusive whether Kv4.1 participates in pain regulation. read more here.
Keywords: kv4 expressed; participates pain; kv4; pain regulation ... See more keywords
The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice
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DOI: 10.1016/j.expneurol.2020.113437
Abstract: The voltage-gated potassium channel Kv4.2 is a critical regulator of dendritic excitability in the hippocampus and is crucial for dendritic signal integration. Kv4.2 mRNA and protein expression as well as function are reduced in several… read more here.
Keywords: dendritic spine; potassium channel; morphology; kv4 ... See more keywords
Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus
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DOI: 10.1016/j.isci.2021.102876
Abstract: Summary The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature… read more here.
Keywords: pattern separation; separation dentate; spatial pattern; separation ... See more keywords
Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2022.2053420
Abstract: ABSTRACT JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus… read more here.
Keywords: kv4 expressed; jztx; kv4; molecular determinants ... See more keywords
Probability of A‐channel rectification (Commentary on Johnston et al., 2008)
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DOI: 10.1111/ejn.15804
Abstract: The voltage-dependent K (Kv) channels generate outwardly rectifying currents with heterogeneous activation and inactivation times. Among them, the A currents via Kv1.4, Kv4.1, Kv4.2 and Kv4.3 are unique because they are of transient types in… read more here.
Keywords: commentary johnston; probability channel; kv4; channel rectification ... See more keywords
JZTX-V Targets the Voltage Sensor in Kv4.2 to Inhibit Ito Potassium Channels in Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00357
Abstract: Kv4 potassium channels are responsible for transient outward K+ currents in the cardiac action potential (AP). Previous experiments by our group demonstrated that Jingzhaotoxin-V (JZTX-V) selectively inhibits A-type potassium channels. However, the specific effects of… read more here.
Keywords: potassium channels; ito potassium; jztx; kv4 ... See more keywords
β Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants
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DOI: 10.3389/fphys.2017.00066
Abstract: The human ventricular cardiomyocyte transient outward K+ current (Ito) mediates the initial phase of myocyte repolarization and its disruption is implicated in Brugada Syndrome and heart failure (HF). Human cardiac Ito is generated primarily by… read more here.
Keywords: splice variants; physiology; human kv4; kv4 ... See more keywords
Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22031419
Abstract: Ion channels are macromolecular complexes present in the plasma membrane and intracellular organelles of cells. Dysfunction of ion channels results in a group of disorders named channelopathies, which represent an extraordinary challenge for study and… read more here.
Keywords: modulation; potassium; pharmacological approaches; channel ... See more keywords