Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine.
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DOI: 10.1016/j.ejphar.2020.173159
Abstract: Transient outward K+ current, Ito, contributes to cardiac action potential generation and is primarily carried by Kv4.3 (KCND3) channels. Two Kv4.3 isoforms are expressed in human ventricle and show differential remodeling in heart failure (HF).… read more here.
Keywords: lidocaine mexiletine; kv4 isoforms; mexiletine; antiarrhythmic drugs ... See more keywords