Molecular simulation of the Kv7.4[ΔS269] mutant channel reveals that ion conduction in the cavity is perturbed due to hydrophobic gating
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100879
Abstract: Mutations in the voltage-gated potassium channel Kv7.4 (encoded as KCNQ4) lead to the early onset of non-syndromic hearing loss, which is significant during language acquisition. The deletion of the S269 pore residue (genetic Δ mutation)… read more here.
Keywords: ion conduction; s269; cavity; kv7 ... See more keywords
Pi(4,5)P2 Modulates Hysteresis and Pharmacology of KV7 Channels
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.624
Abstract: KV7 channels are critical components of the plasma membrane in many excitable cells. The main function of KV7 channels is to contribute to the maintenance of the resting potential, thus regulating cellular electrical excitability. In… read more here.
Keywords: kv7 kv7; kv7; pharmacology; hysteretic behavior ... See more keywords
Ca2+-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels
Sign Up to like & getrecommendations! Published in 2017 at "Channels"
DOI: 10.1080/19336950.2017.1388478
Abstract: ABSTRACT In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. The proximal Kv7.1… read more here.
Keywords: ca2 calmodulin; cam; terminus; pip2 ... See more keywords
Recombinant Production, Reconstruction in Lipid–Protein Nanodiscs, and Electron Microscopy of Full-Length α-Subunit of Human Potassium Channel Kv7.1
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297918050097
Abstract: Voltage-gated potassium channel Kv7.1 plays an important role in the excitability of cardiac muscle. The α-subunit of Kv7.1 (KCNQ1) is the main structural element of this channel. Tetramerization of KCNQ1 in the membrane results in… read more here.
Keywords: protein; microscopy; potassium channel; kv7 ... See more keywords
Genetic inhibition of KV7/M-channels increases the excitability of bronchopulmonary vagal nociceptive nerves
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732751
Abstract: The KV7/M-channel, encoded by Kcnq2-5 genes, generates a “braking” potassium current (IM) and contributes to the regulation of neuronal excitability. We have previously reported that the vagal sensory nerves terminated in the mouse lungs expressed… read more here.
Keywords: kv7; nodose neurons; kcnq2; physiology ... See more keywords
Kv7 channel isoforms contribute to H2O2-mediated vasodilation in the ischemic heart after exercise training
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733976
Abstract: Ischemic heart disease is a multifaceted pathological manifestation that continues to impose a significant burden on individuals and the healthcare system. As a potential therapeutic modality, exercise training has been reported to induce vascular adaptations… read more here.
Keywords: kv7; exercise training; vasodilation; physiology ... See more keywords
Inhibition of Kv7/M Channel Currents by Fangchinoline
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacology"
DOI: 10.1159/000527464
Abstract: Introduction: Voltage-gated Kv7/M potassium channels play an essential role in the control of membrane potential and neuronal excitability. Fangchinoline, a bisbenzylisoquinoline alkaloid, displays extensive biological activities including antitumor, anti-inflammatory, and antihypertension effects. In this study,… read more here.
Keywords: channel currents; kv7; kv7 channels; kv7 channel ... See more keywords
The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0192122
Abstract: Pre-eclampsia is associated with altered maternal and placental vascular reactivity. Kv7 channels (encoded by KCNQ 1–5 genes) are a potential contributor to the regulation of vascular tone in CPAs (chorionic plate arteries) during normal pregnancy.… read more here.
Keywords: pre eclampsia; chorionic plate; kv7; expression ... See more keywords
Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.00105
Abstract: M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In… read more here.
Keywords: itch; neuronal excitability; itch mice; induced itch ... See more keywords
Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1138556
Abstract: Chronic pain is highly prevalent and remains a significant unmet global medical need. As part of a search for modulatory genes that confer pain resilience, we have studied two family cohorts where one individual reported… read more here.
Keywords: kv7 specific; kv7; ipsc; sensory neuron ... See more keywords
A Novel Kv7.3 Variant in the Voltage-Sensing S4 Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and in vitro Rescue by β-Hydroxybutyrate
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.01040
Abstract: Pathogenic variants in KCNQ2 and KCNQ3, paralogous genes encoding Kv7.2 and Kv7.3 voltage-gated K+ channel subunits, are responsible for early−onset developmental/epileptic disorders characterized by heterogeneous clinical phenotypes ranging from benign familial neonatal epilepsy (BFNE) to… read more here.
Keywords: voltage; neonatal epilepsy; segment; voltage sensing ... See more keywords