Inhibitory effects of retigabine, a Kv7 channel activator, on mechanosensitive primary bladder afferent activities and nociceptive behaviors in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.22920
Abstract: Kv7 voltage‐gated potassium channels have been suggested to modulate mechano‐afferent transduction and nociception in the bladder. We investigated the effects of retigabine, a Kv7 channel activator, on rhythmic bladder contractions (RBCs), and single‐unit afferent activities… read more here.
Keywords: channel activator; bladder; retigabine kv7; kv7 channel ... See more keywords
Spinal Actions of the NSAID Diclofenac on Nociceptive Transmission in Comparison to the Kv7 Channel Opener Flupirtine
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DOI: 10.1016/j.neuroscience.2020.05.052
Abstract: NSAIDs are the drugs most commonly used to alleviate pain. Despite being a heterogeneous group of compounds, all of them share a mechanism of action based on blockade of COXs enzymes, which confers them anti-inflammatory… read more here.
Keywords: channel; kv7 channels; kv7 channel; activity ... See more keywords
Inhibition of Kv7/M Channel Currents by Fangchinoline
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DOI: 10.1159/000527464
Abstract: Introduction: Voltage-gated Kv7/M potassium channels play an essential role in the control of membrane potential and neuronal excitability. Fangchinoline, a bisbenzylisoquinoline alkaloid, displays extensive biological activities including antitumor, anti-inflammatory, and antihypertension effects. In this study,… read more here.
Keywords: channel currents; kv7; kv7 channels; kv7 channel ... See more keywords
The Kv7 Channel and Cardiovascular Risk Factors
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DOI: 10.3389/fcvm.2017.00075
Abstract: Potassium channels play a pivotal role in the regulation of excitability in cells such as neurons, cardiac myocytes, and vascular smooth muscle cells. The KCNQ (Kv7) family of voltage-activated K+ channels hyperpolarizes the cell and… read more here.
Keywords: risk factors; cardiovascular risk; channel cardiovascular; kv7 channel ... See more keywords
M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00513
Abstract: Neuronal Kv7 channel generates a low voltage-activated potassium current known as the M-current. The M-current can be suppressed by various neurotransmitters that activate Gq-coupled receptors. Because the M-current stabilizes membrane potential at the resting membrane… read more here.
Keywords: neuronal kv7; channel; kv7 channel; current suppression ... See more keywords